Introduction The global lung function initiative (GLI) 2012 introduced new multi‐ethnic spirometry reference values for numerous ethnicities. Objectives The aim of this study was to investigate the suitability of the GLI reference values for the adult Jordanian population. Methods About 1875 (1029 females and 846 males) healthy non‐smoking adults were enrolled from several locations in Jordan. Spirometry tests were performed. z‐scores and predicted normal values were calculated for each participant using GLI 2012 equations in addition to other local equations from the Middle East. Results Our results indicated that none of the GLI 2012 or other regional equations studied produced an acceptable fit to our data. Conclusion A need to formulate a specific equation for the Jordanian population is urgently required to better evaluate their respiratory conditions.

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