Cancer of breast has emerged as the leading site of cancer in most urban populations of India. For the year 2007, there have been an estimated 82,000 new cases of cancer Breast in India. It is rapidly replacing cancer of cervix as the most important leading site of cancer among women. The data collected over the years from five urban population based cancer registries namely Bangalore, Bhopal, Chennai, Delhi and Mumbai, under the network of National Cancer Registry Programme (NCRP) have shown a statistical rising trend in the incidence rate of breast cancer. In hospital-based cancer registries, cancer of the breast is the leading site of cancer in Mumbai and Thiruvananthapuram, second leading site in Bangalore, Dibrugarh and Chennai. Cancer of breast constitutes 14.3 to 30.0% of all cancers in women in these HBCRs. The report on 'Development of an Atlas of Cancer in India' showed that Chandigarh (39.5), North Goa (36.8), Aizawl (36.2) and Panchkula (34.6) had the higher microscopic incidence rates of breast cancer compared to that seen in Delhi PBCR that had the highest rate among all PBCRs.

An occupational injury surveillance study (record study of five years duration) was conducted involving the workers of a fertilizer producing industry in eastern India to assess whether the risk of occupational accidents in temporary piece rated workers was higher in comparison to the permanent time rated workers. At the same time, to collect the personal details of the workers who have worked in the industry in the study period, an interview was also conducted. Mean age of temporary piece rated workers and permanent time rated workers were (35.9 ± 12.5) and (35.3 ± 11.4) respectively. Distribution of other variables like nature of work, level of education, experience, habits were also very similar between the two worker groups. Accident incidence rate, accident frequency rate and accident severity rate were found to be significantly higher in temporary piece rated workers. This difference was more prominent in case of time-loss accidents than in no timeloss accidents. Relative risk has varied from 2.3 to 18.0 in case of time-loss accidents. In case of no time-loss accidents, it has varied from 1.1 to 2.6. When relative risk is considered after taking both types of accidents together, it has ranged from 1.2 to 3.5. This study concluded that the temporary piece rated workers are more vulnerable to occupational accidents.

Background:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003–2008.Methods:Age-adjusted incidence rates (AARs) per 100 000 person-years were calculated by direct method using the world standard population, and analysed by ethnic group (Bhutia, Rai and other).Result:There were a total of 1148 male and 1063 female cases of cancer between 2003 and 2008 on the Sikkim PBCR. The overall AARs were 89.4 and 99.4 per 100 000 person-years in males and females, respectively. Incidence rates were highest amongst the Bhutia group (AAR=172.4 and 147.4 per 100 000 person-years in males and females, respectively), and the largest difference in rates were observed for stomach cancers with AARs being 12.6 and 4.7 times higher in the Bhutia group compared with other ethnic groups in males and females, respectively.Conclusion:These observations call for further epidemiological investigations and the introduction of screening programmes.

Objective: Prevalence is a statistic of primary interest in public health. In the absence of good follow-up facilities, it is often difficult to assess the complete prevalence of cancer for a given registry area. An attempt is made to arrive at the complete prevalence including limited duration prevalence with respect of selected sites of cancer for India by fitting appropriate models to 1, 3 and 5 year cancer survival data available for selected registries of India. Methodology: Cancer survival data, available for the registries of Bhopal, Chennai, Karunagappally, and Mumbai was pooled to generate survival for the selected cancer sites. With the available data on survival for 1, 3 and 5 years, a model was fitted and the survival curve was extended beyond 5 years (up to 30 years) for each of the selected sites. This helped in generation of survival proportions by single year and thereby survival of cancer cases. With the help of estimated survived cases available year wise and the incidence, the prevalence figures were arrived for selected cancer sites and for selected periods. In our previous paper, we have dealt with the cancer sites of breast, cervix, ovary, lung, stomach and mouth (Takiar and Jayant, 2013). Results: The prevalence to incidence ratio (PI ratio) was calculated for 30 years duration for all the selected cancer sites using the model approach showing that from the knowledge of incidence and P/I ratio, the prevalence can be calculated. The validity of the approach was shown in our previous paper (Takiar and Jayant, 2013). The P/I ratios for the cancer sites of lip, tongue, oral cavity, hypopharynx, oesophagus, larynx, nhl, colon, prostate, lymphoid leukemia, myeloid leukemia were observed to be 10.26, 4.15, 5.89, 2.81, 1.87, 5.43, 5.48, 5.24, 4.61, 3.42 and 2.65, respectively. Conclusion: Cancer prevalence can be readily estimated with use of survival and incidence data.

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Introduction: The Q-angle is defined as the acute angle formed by the vectors for combined pull of the quadriceps femoris muscle and the patellar tendon. It has a great clinical and biomechanics significance. The present study was planned so as to study Q-angle in healthy young adult individuals and establish its relationship with different anthropometric parameters. Material and methods:The subjects for the study were normal healthy young adult medical students from A.C.S. medical college, Chennai, India.148 subjects (80 girls and 68 boys)were studied. Males and females between the age of 18-20 years were included in the study. Q-angle was measured using standard goniometer. The Q-angle in degree was measured on both sides. These Q-angles were correlated with various anthropometric parameters (height, weight, BMI, WHR, pelvic width, femur length).Results: The mean Q-angle in males on left side was 8.1+1.83and that on right side was 8.6 +2.20The mean Q-angle in females on left side was 8.8+ 2.33 and that on right side was 8.9 + 2.52. There were no significant bilateral differences The Q-angle (Left) and Q-angle (Right) are significantly correlated with Weight (Kg), Waist (cm) and Hip (cm). However, these angles are not correlated with Weight for height or Waist for Hip ratio, pelvic width and femur length in females.In case of males, height, BMI, Pelvic width measurements were found to be correlated with Q-Left and Q-Right angle. Femur length was correlated only with Q-Left angle while there was no correlation with Q-Right angle. Conclusion:No significant differences in both gender was also noted, No significant bilateral differences were seen. According to our study Q-angle does not vary with the age. Several anthropometric measures on correlating with Q-angle signify that irrespective of gender higher Q-angles are seen with those having high BMI, increased waist and hip-circumference.

Manganese-induced early biochemical changes and effects of supplementation of magnesium nitrate (Mg(NO 3 ) 2 ) and antioxidant vitamins (A, C, D and E) were studied in rats intoxicated with manganese. Significant elevation in the level of chlorides in plasma, erythrocytes, liver and cerebellum, and a decrease in plasma inorganic phosphate (pi) with an increase in liver pi were observed in animals exposed to manganese as compared to controls. The level of erythrocyteacid labile phosphate (ALP), nicotinamide adeninedinucleotide (NAD + ) and plasma sialic acid (Nacetylneuraminic acid, NANA) also increased significantly. Elevated levels of chlorides in plasma, erythrocytes and cerebellum reversed to normal control values whereas liver chlorides restored partially by the supplementation of Mg(NO 3 ) 2 . Vitamins supplementation was effective to reverse chlorides level in erythrocytes, liver and cerebellum. Decreased level of pi in plasma and the highly elevated level of erythrocyte ALP were also recovered in animals received Mg(NO 3 ) 2 in addition to MnSO 4 . However, such effect of Mg(NO 3 ) 2 was not seen in lowering the elevated level of NANA that restored by the administration of vitamins. Thus, the early alterations in plasma levels of chlorides, pi, and NANA and erythrocyte-ALP seem to be an indicative of early manganese toxicity while Mg(NO 3 ) 2 and vitamins supplementation appear to provide, at least in part, protection against manganese toxicity.

The present communication seeks to describe an alternate approach of arriving at cut-off levels using ratio of percentiles for (i) differentiating normal children from the undernourished ones, and (ii) identifying the severely undernourished group of children in the community on the basis of body weight and height. It also examines validity of the cut-off levels presently used of weight for age (Gomez and Indian Academy of Paediatrics classification) and height for age parameters. 1. The cut-off levels are independent of the reference standard and, as such, the same cut-off levels could be used irrespective of the standards. 2. It is desirable to have separate cut-off levels for preschool and school age groups. The use of common cut-off points for both the age groups seems to result in loss of sensitivity of the order of over 5 per cent. 3. The use of the 90 per cent cut-off level in the Gomez classification misclassifies some of the normals as undernourished, thereby tending to overestimate the problem of undernutrition in communities. 4. The body weight groups based on the suggested cut-off points do bear a relationship to the prevalence of signs of PEM--the greater the weight deficit, the higher the prevalence of signs of PEM in preschool children.