Study of Coagulation profile in preeclampsia and eclampsia comprised of 258 cases which were categorized as preeclampsia, eclampsia and control group with 86 cases in each group. A total number of 258 patients were studied which were categorized as the control group, preeclampsia group and eclampsia group with 86 cases in each. Preeclampsia was further classified as mild preeclampsia (48/86) and severe preeclampsia (38/86). Among all patients, thrombocytopenia was found in 61% of patients. All patients in the control group had platelet counts within the normal range. The method used in the present study is an analytical case-control study, carried out in the Department of Pathology in our institute. Our study includes cases of preeclampsia and eclampsia coming to the Department of Obstetrics and Gynaecology during the period of two years from May 2015 to April 2017. Newly diagnosed Preeclampsia and eclampsia patients in the third trimester of age 18 to 30 years. From this study, it can be concluded that coagulation profile can help to assess the severity of preeclampsia and eclampsia and thus can help to reduce complications if treated early. Thus as inconclusive of this study of coagulation profile has significant value and impact on management and outcome of cases of preeclampsia and eclampsia.
Objective: Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) are clinically and biologically diverse phenotypic diseases amongst hematological malignancies. The current study objectives were to diagnose and classify cases of AL as per revised 4th edition of WHO 2016 classification of AL’s and study their clinicopathological profiles. Material and Method: This cross-sectional, observational study included 68 patients, diagnosed with AL were recruited. Diagnosis was based on peripheral blood smear examination, bone marrow aspiration, flowcytometry, and cytogenetic and molecular studies. Results: Sixty-eight cases of AL were diagnosed in a period of 2 years, where 25 cases were of ALL and 43 cases were of AML. In the subclassification of AML as per WHO 2016, 20 cases were of AML, RGA, 21 cases were of AML, NOS, and 2 cases were of AML, MRC. In AML, RGA, APL with PML-RARA positive cases were 10 out of 20 cases, AML with (8;21) RUNX1-RUNX1T1 were 7/20 cases; there were two cases of AML with mutated NPM1 gene and one case of AML with biallelic mutation of CEBPA. In AML, NOS subcategory AML with maturation was more common with 9/21cases. In subcategory of ALL, B-ALL was more common than T-ALL. B-ALL, NOS was more common than B-ALL, RGA and we had 1 case of NK cell Leukemia. Conclusion: The application of revised 4th edition WHO 2016 classification confers uniformity in reporting acute leukemia cases that aids in the treatment by using targeted therapies and helps in the prediction of prognosis. The WHO classification for acute leukemias is very objective, therapy oriented and the need of the hour.
The present research has been conducted to find the utility of image-guided fine-needle aspiration cytology in the diagnosis of thoracoabdominal lesions. It also has attempted to study the frequency of distribution of thoracoabdominal lesions. At the same time tried to classify various thoracoabdominal lesions with the help of image-guided fine-needle aspiration cytology. The study of image-guided FNAC of thoracoabdominal lesions was carried out for twenty-four months, i.e. from MAY 2014 to APRIL 2016, which included 80 cases. Most patients (80%) were in the 5th-7th decade of life. All cases of ovarian lesions were diagnosed as malignant tumours on cytology, 08 were diagnosed as adenocarcinoma and one case of granulosa cell tumour. 06 out of 08 cases which diagnosed as adenocarcinoma on cytology, were confirmed on histology and diagnosed as mucinous cystadenocarcinoma(03 cases) and papillary serous carcinoma (03 cases). A case of malignant granulosa cell tumour was diagnosed on cytology and confirmed on histopathology. A case of mesenteric lymphadenopathy was diagnosed as granulomatous inflammation, suggestive of tuberculosis and was confirmed on histopathology with 100% accuracy. This was the only paediatric case in our study. A case of para-spinal abscess of thoracic vertebrae was diagnosed as chronic inflammation on guided FNAC, and the etiological agent was identified with histopathology as actinomyces.
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