New Mn(i)-based photoCORMs with a fac-{Mn(CO)3} moiety exhibit facile CO release upon simple exposure to light within the phototherapeutic region (no two photon excitation required).
As part of the quest for new gold drugs, we have explored the efficacy of three gold complexes
derived from the tuberculosis drug pyrazinamide (PZA), namely, the
gold(I) complex [Au(PPh3)(PZA)]OTf (1, OTf
= trifluoromethanesulfonate) and two gold(III) complexes [Au(PZA)Cl2] (2) and [Au(PZO)Cl2] (3, PZO = pyrazinoic acid, the metabolic product of PZA) against two
mycobacteria, Mycobacterium tuberculosis and Mycobacterium smegmatis. Only
complex 1 with the {Au(PPh3)}+ moiety
exhibits significant bactericidal activity against both strains. In
the presence of thiols, 1 gives rise to free PZA and
{Au(PPh3)}-thiol polymeric species. A combination of PZA
and the {Au(PPh3)}-thiol polymeric species appears to lead
to enhanced efficacy of 1 against M. tuberculosis.
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