CO release from Mn(i)-based photoCORMs with single photons in the phototherapeutic region

Abstract

New Mn(i)-based photoCORMs with a fac-{Mn(CO)3} moiety exhibit facile CO release upon simple exposure to light within the phototherapeutic region (no two photon excitation required).

Investigation of the CO releasing ability of azachalcone bound Mn(I) tricarbonyl complexes and their antiproliferative properties

“…The bond angle N(1)-Mn-O (4) = 78.3(1) , N(1)-Mn-C(2) = 171.1(2) and O(4)-Mn-C(3) = 174.5(2) deviate considerably from that of an ideal octahedral geometry. Among the three Mn-C (CO) bonds, the one trans to Br is the longest (1.840(7) Å) and subsequently the axial CO has the shortest bond length (1.05(1) Å), this is in agreement with those reported by Mascharak et al [40,43] The two CO groups trans to the azachalcone ligand have slightly different bond lengths. The CO which is trans to the N1 atom has a bond length of 1.131(6) Å while the one which is trans to O(4) is 1.140(6) Å.…”

“…[ 25,35,39–42 ] Recently, Mascharak et al reported photoCORMs that have MLCTs in the 750‐ to 785‐nm range, the highest reported so far. [ 43 ] Among these, the complexes containing N and O as the chelating atoms such as acenaphthylen‐1‐one and quinolone‐8‐one exhibited MLCT at 630 and 785 nm, respectively. Thus, it can be concluded that even if the ligating atoms are same, the type of ligand framework can immensely affect the position of the MLCT.…”

Release of CO and Production of 1O2 from a Mn-BODIPY Photoactivated CO Releasing Molecule with Visible Light

“…One of the main challenges in designing an efficient photoCORM is activation by light in the phototherapeutic window (600–950 nm). To date, various strategies, including ancillary ligand modifications, , multiphoton excitation, , mixing with a triplet-state photosensitizer, quantum dots, upconverting nanoparticles, or as previously reported by our group, coupling with a visible light absorbing metal complex, and so forth, have been employed to activate the photo-CO dissociation under visible and NIR irradiation. Alternatively, the use of dye photosensitizers as light-harvesting components of the design allows for visible light-activated photoCORMs …”

A Density Matrix Renormalization Group Study of the Low‐Lying Excited States of a Molybdenum Carbonyl‐Nitrosyl Complex

“…In a similar manner, carbon monoxide (CO), although mostly known for its strong toxicity due to strong binding to hemoglobine, was recently discovered to be produced endogenously in small amounts and responsible, similarly to NO, for a variety of physiological effects [19] . This has also triggered the development of targeted CO photoreleasing compounds ( photoCORMs ) [20–27] …”

“… [19] This has also triggered the development of targeted CO photoreleasing compounds ( photoCORMs ). [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]…”