Sweet potato leaves (Ipomea batatas (L) Lam ) are empirically used by people in some regions as traditional medicines to treat dengue fever and as anti-cancer because of their high antioxidant content. This study aims to see the effect of sweet potato leaf water fraction as a hepatoprotector on male white rats induced by paracetamol. Sweet potato leaves were extracted by maceration using 70% ethanol for 8 days then fractionation was carried out. The hepatoprotector test was carried out on 25 rats grouped in 5 groups treated orally for 7 days, namely negative controls given aquades, positive controls were given hepamax dose 59.06 mg / kgBB, groups I, II and III were given a fraction of sweet potato leaf water with a dose of 4.77 mg / kgBB, 9.54 mg / kgBB, and 19.08 mg / kgBB then male white rats induced by paracetamol orally at a dose of 1350mg / kgBB for 1 day. The increase in SGPT and SGOT levels was measured on day 9 using spectrophotometry then analyzed by ANOVA method. The results of SGPT analysis showed that groups I, II and III were significantly different from the negative controls (sig 0,000), and had the same effect on positive controls (sig 0.144) in suppressing SGPT level increases while in the analysis results the SGOT group III levels were significantly different from controls negative (sig 0,000) and significantly different from group I, II (sig 0.30 and 0.24), and have the same effect as positive controls (sig 0.392). The third dose (19.08 mg / kgBB) showed the best suppression increased and was not significantly different from statistically positive controls. Based on the research it was concluded that the fraction of sweet potato leaf water could be used as a hepatoprotector for male white rats induced by paracetamol. Keywords: Hepatoprotector, Paracetamol, Sweet Potato Leaves.
Malaria is a public health problem in Indonesia, especially those living in isolated areas. This is published in Presidential Regulation No. 5/2010 concerning the National Medium Term Development Plan for malaria endemic areas, which are divided into high, medium and low endemic areas. High endemic if the API is greater than 50 out of 1,000 population in the provinces of Maluku, Papua, North Sumatra and East Nusa Tenggara. Moderate endemic if the API is 1 to less than 50 dari 1,000 population in the provinces of Aceh, Bangka Belitung, Jambi and West Nusa Tenggara. Low endemic if the API is 0-1 per 1,000 population in Kalimantan, Sulawesi, and parts of Java. This study aims to determine the evaluation of the use of antimalarial drugs with the characteristics of age, sex, and type of malaria plasmodium at the Hanura Public Health Centre based on the criteria of the right indication, the right drug, the right dose, the right interval of drug administration (4T). This research is a descriptive research with purposive sampling method. Collection of prescription data and medical records in January-December 2018. The results showed that in cases of Malaria based on age, the most common cases occurred in the age range of 56-65 years, amounting to 99.6%, based on sex experienced in men by 77.41%, based on body weight the most occurred at 41-59 kg at 45.16%, based on the type of plasmodium experienced plasmodium vivax mostly at 84.95%. Based on these data, it was concluded that the evaluation of the use of antimalarial drugs based on 4T criteria was 100% accurate indication, 100% correct drug, 72.04% correct dose, 98.92% correct interval of drug administration. Keywords: Malaria vivax, treatment, Puskesmas, 4T
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