Our group already demonstrated that europium hydroxide nanorods (EHNs) show none or mild toxicity in C57BL/6 mice even at high dose and exhibited excellent pro-angiogenic activity towards in vitro and in vivo models. In the present study, we evaluated the in vivo cytogenetic toxicity of intraperitoneally administered EHNs (12.5-250 mg/kg/b.w.) in male and female Swiss albino mice by analyzing chromosomal aberrations (CAs), mitotic index (MI), micronucleus (MN) from bone marrow and peripheral blood. Furthermore, we performed the cytogenetic toxicity study of EHNs towards Chinese hamster ovary (CHO) cells, in order to compare with the in vivo results. The results of CA assay of mice treated with EHNs (12.5-125 mg/kg/b.w.) showed no significant change in the formation of aberrant metaphases compared to the control group. Also, there was no significant difference in the number of dividing cells between the control group and EHNs-treated groups observed by MI study, suggesting the non-cytotoxicity of EHNs. Additionally, FACS study revealed that EHNs do not arrest cells at any phase of cell cycle in the mouse model. Furthermore, MN test of both bone marrow and peripheral blood showed no significant differences in the induction of MNs when compared with the control group. In vitro results from CHO cells also support our in vivo observations. Considering the role of angiogenesis by EHNs and the absence of its genotoxicity in mouse model, we strongly believe the future application of EHNs in treating various diseases, where angiogenesis plays an important role such as cardiovascular diseases, ischemic diseases and wound healing.
A shorted magneto electric dipole with orthogonal dual polarization is designed for modern wireless communications. The proposed antenna is a wideband dual-polarized antenna consisting of magneto electric dipoles, which are fed by novel hook-shaped strip feeds. The antenna proposed in this paper is simulated using EM simulation software called high-frequency structure simulator. The simulated and measured results are presented. This antenna achieves 45.4% of impedance bandwidth of −10 dB RL for frequency range from 1.7 to 2.7 GHz. This frequency range covers the wireless communications applications like GSM 1800/1900, WCDMA, Bluetooth, Wi-Fi, etc.
A high performance substrate integrated waveguide (SIW) slotted array antenna with low sidelobe level and optimum gain at 28 GHz is designed, and experimental results are presented with simulated data. In order to achieve a low sidelobe level, Chebyshev power coefficients in the form of slot displacements are applied to the SIW array antenna. A MATLAB program has been written to find these slot displacements. This work entails investigating and designing the optimum microstrip to SIW transition over the Ka-band, designing a 1 × 8 slotted SIW array antenna, and finally applying the Chebyshev power coefficients to the slots of the 1 × 8 SIW array antenna. The fabricated prototype of a 1 × 8 SIW slotted array antenna is tested, and its performance is studied in terms of gain and half power beam width (HPBW), compared with simulations. The measured results of the 1 × 8 slotted SIW array antenna at 28 GHz have a |S 11 | of better than −20 dB, a gain of 13 dB, and an HPBW of 17 • . The overall dimensions of the design at 28 GHz are 7.143 mm × 51.8 mm × 0.254 mm (0.667λ o × 4.84λ o × 0.023λ o = 0.0766λ 3 o mm 3 ).
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