Initial results of the Australian Therapeutic Trial in mild hypertension REPORT BY THE MANAGEMENT COMMITTEE. Design of the study The study was a placebo-controlled, single blind, randomized therapeutic trial in men and women aged 30-69 years with diastolic pressures (phase 5 diastolic blood pressure) ranging from 95 to 109 mmHg. All subjects were free of evidence of target organ damage. Subjects were admitted according to the mean of four diastolic readings over two screening visits and were randomly assigned to active or placebo groups. Commencing in July 1973, 103 643 subjects were screened and 3943 entered the study, which was conducted in four centres. Tablets, active or placebo, were commenced at a third visit if diastolic pressure was again 1 9 5 mmHg. However, if it was (95 mmHg at this visit, tablets were withheld but the subjects continued to be observed, as for those taking tablets, at 4 months intervals. Subsequently, if diastolic pressure rose to 95 mmHg or more, tablets were commenced according to the original assigned randomized group. This report concerns the 3323 subjects who commenced taking tablets.
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