No abstract

The present study was designed to determine the age at which menarche occurs among school girls in Buldana district of Maharashtra state, India. A survey was conducted among 488 girls by writing the questionnaire from schools in the selected area. Respondents completed a questionnaire that recorded age at first menstruation by the recall, residential status, type of education, and diet/food habit. The mean age at menarche was 13.44 ± 0.75 years. Most girls (72.95%) of the respondents were found of normal age menarche (12–14 years), 27.05% of late-type menarche (> 14 years), and 0% were of early menarche (less than 12 years). Our study suggests an influence of school education, residential area, and diet/food habit on menarcheal age.

In the field of molecular modeling, docking may be a method which predicts the well-liked orientation of any molecule to a receptor to make a stable complex. Knowledge of the well-liked orientation successively could also be able to predict the strength of association or binding affinity between two molecules using, for instance, scoring functions. Cyclooxygenase-2 (COX-2) inhibitors block cyclooxygenase-2 (COX-2), an enzyme that promotes inflammation. COX-2 enzyme converts to prostaglandin via arachidonic acid, causing pain and inflammatory responses. They are mainly present in places of inflammation and are responsible for formation of prostanoids (prostacyclins, prostaglandins and thromboxane) as part of the inflammatory response. COX-2 inhibitors are used to relieve pain raised from the inflammation. In the present study, the marketed COX-II inhibitors are subjected for the docking study and the drug likeness study which validate that the drugs show the optimum binding energy and drug likeness score with optimum bioactive score.