Otorhinolaryngological infections are common pathologies especially in children, their clinical manifestations are varied. Knowledge of the microbial ecology of these infections in the ENT sphere may be important for the choice of probabilistic antibiotic therapy, but also for adapting and adjusting the treatment in therapeutic failure situations and complications. This is a descriptive retrospective study between January 2017 and August 2018. Including all samples taken in the ENT field in patients hospitalized in the ORL service of Med VI University Hospital of Marrakech. Of the 115 samples, bacterial confirmation was found in 87% of cases. The bacteriological profile was dominated by Gram-positive bacteria in 52% of cases. Isolated strains were mainly represented by Streptococcus (28%), followed by Staphylococcus aureus (22%). Enterobacteria accounted for 34% of isolates dominated by Klebsiella pneumoniae found in 20.5% of cases. The study of antibiotic susceptibility of isolated strains revealed a penicillin sensitivity of 98% in isolates of Streptococcus pneumoniae. A 75% sensitivity to amoxicillin was revealed in Enterococcus and all strains of Staphylococcus aureus were sensitive to meticillin. In enterobacteria, resistance to C3G was 18%, 38% to fluoroquinolones, 35% to cotrimoxazole and 29% of strains were resistant to Gentamycin. The multi-resistant strains of Pseudomonas aeruginosa were found in 8% of cases.
Synthesis of New Derivatives of β-Lactam-ContainingAntibiotics Formed with Certain Sulfonyl Chlorides. -New semisynthetic penicillins (III) and cephalosporins (cf. (V)) bearing a sulfamoyl group are synthesized and evaluated for their antimicrobial activity. Some of them show promising antibacterial activity. -(ABDEL-HALIM, A. M.; ABDEL-AZIZ, R. M.; ABDEL-NASSER, G.; HASHEM, A. I.; J.
Synthesis and Antimicrobial Activity of a Dihydroampicillin and a Dihydrocephalexin.-Dihydroampicillin (III) and dihydrocephalexin (V) exhibit enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin. -(HASHEM, A. I.; SHABAN, M. E.; ABDEL-AZIZ, R.; ABDEL-NASSER, G.; Arch.
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