The general public frequently has dry skin. Erythema, edoema, exudation, and crusting are signs of an inflammatory reaction when dry skin is present together with chapping or underlying dermatoses. The most common skin conditions where dry skin may be a symptom include ichthyosis, psoriasis, and dermatitis/eczema. Primary and secondary infections can occur in these conditions. Therapeutically, secondary skin infections, such as dermatoses in atopic dermatitis, psoriasis, and infected wounds, are more problematic than original skin infections. 1,2 One of the dermatitis kinds in which primary and secondary infections are likely to occur is atopic dermatitis (AD). Due to skin sores that were damaged by scratching and became vulnerable to bacterial infections, impetigo became prevalent in AD. 3 Pustules and crusts are the first symptoms of secondarily infected atopic dermatitis. because secondary symptoms of AD are associated with increased stratum corneum Staphylococcus aureus colonization, alteration of the epidermal barrier, and faulty innate immunological responses. 4 When a person has pustular psoriasis (PP), Staphylococcus aureus can cause secondary infections that can arise from pustules and, in rare cases, blood cultures. 5 Topical fusidic acid, topical mupirocin, oral penicillins that are resistant to penicillinase, including oxacillin, and oral cephalosporin are the antibiotics prescribed for secondary infections of AD. It is recommended for the topical treatment of primary and secondary skin infections in primary pyodermas like impetigo, folliculitis, furunculosis, and ecthyma, as well as secondary infected dermatoses like eczema, psoriasis, and AD. Mupirocin is a novel topical antibacterial agent and metabolite of Pseudomonas fluorescens fermentation. In order to effectively block bacterial protein synthesis, mupirocin forms a link with the enzyme isoleucyl-t-RNA synthetase. This prevents isoleucine from being incorporated into protein chains. Mupirocin exhibits activity against gram-positive cocci in vitro, including Streptococcus pyogenes, Staphylococcus aureus, and other b-hemolytic streptococci. Due to its fast break down into an inactive metabolite in the plasma when administered systemically, mupirozin is only utilized as a topical agent. 6,7 To directly treat cutaneous problems, a topical administration device applies a drug-containing formulation to any external body surface by injunction, spraying, dusting, or injection. Topical gel is suitable for the treatment of dermatological conditions, including in scalp conditions like psoriasis, because it is simple to apply and wash off, easy to apply on hair-bearing areas, and nongreasy. The hydrophobic drug delivery is more difficult and results in a nonocclusive film, which restricts their usefulness as an occlusive emolliating vehicle. 8 In essence, emulgels, also known as emulsified gels, are biphasic systems that have an aqueous gel mixed with a lipid phase, closely resembling a cream. Greaseless, calming, protecting, thixotropic, readily spreadabl...