Objective: The present study was designed to formulate and evaluate the orodispersible tablets of lamotrigine after enhancing its solubility.
Methods: Lamotrigine was made into an inclusion complex with eudragit E 100 my kneading and mass extrusion method and later this mixture is compressed into orodispersible tablet using various super disintegrants and co-processed excipients to reduce the disintegration time for providing prompt action through rapid drug release.
Results: Lamotrigine ODTs containing F-melt (F1-3%, F2-5%) dispersed in lesser time of (9±0.11) and (21±0.58) compared to formulations with polyplasdone XL-10 and primellose as super disintegrants respectively with F1 showing short wetting time. The water absorption was also was found to be more for formulation with 3% F-Melt.
Conclusion: Lamotrigine orodispersible tablets were prepared by direct compression technique by using 3% and 5% of three super disintegrants (f-melt, primellose and polyplasdone XL-10). Disintegration time of F1 (3% f-melt) formulation was found to be least (7 sec).
The main objective of this work is to develop mucoadhesive tablet of Fluvastatin sodium, is a sodium salt of a synthetic lipid-lowering agent with potential anti neoplastic activity by employing natural and synthetic polymer and overcome bioavailability related problems and also reduce frequency of administration. Buccal tablets were prepared using HPMC K4M, K15M and Xanthum gum for release retardation, Carbopol 934 for bio adhesion and Chitosan for permeation enhancement. Ethyl cellulose was utilised for backing membrane. It was observed that the release rate slowed down with increasing concentration of carbopol 934 and release rate increased with carbopol 934 and Na CMC from 1:1 to 1:2 ratios in F16 to F 20.NaCMC containing formulations showed better bio adhesion than the HPMC K4M & Carbopol 934.
Objective: The objective of the study was to determine the prevalence of medication errors occurring in a multispecialty hospital in Warangal.
Methods: A prospective observational study was conducted in Rohini Superspeciality Hospital, Hanamkonda, Warangal, from October 2018 to March 2019, to study the prevalence of medication errors.
Results: In this study, 500 patients were selected, of which 160 were identified with medication errors. Two hundred and seventy-one medication errors were identified among these patients, of which 100 (60.63%) patients were male and 24.37% of patients were female.
Conclusion: This present study manifests that medication errors were predominate in males than in females and also the common age group was 50–60 years.
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