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Hand infections are common and range from minor nail fold or pulp infections to severe necrotizing sepsis (often in the presence of other significant co-morbidity). We discuss general principles of the surgical management of soft tissue infection, the microbiology of hand infection and antibiotic policy. Cellulitis, abscess, and specific hand infections are covered, including flexor tendon sheath infection, intra-articular sepsis, and bites (human and animal). The chapter concludes with osteomyelitis and chronic infections, including leprosy, and other conditions which can mimic infection.