The present work was aimed that the two Ruthenium compounds namely, [Ru(A) 2 (B)]Cl 2 , where A = 1,10-phenanthroline; B = 2-NO 2 -phenyl thiosemicarbazone (Compound R 1 )/2-OH-phenyl thiosemicarbazone (Compound R 2 ) have been tested for antibacterial activity at the concentrations of 1 mg/mL against various Gram-Positive organisms (Lactobacillus, Staphylococcus pyrogenes, Bacillus subtilis, Staphylococcus aureus & Bacillus megatarium) and Gram-Negative organisms (Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Enterobacter aerogenes, Salmonella paratyphi, Klebsiella pneumonia & Proteus mirabilis). The compounds were also tested for antifungal activity against Aspergillus clavatus, Aspergillus niger, Colletotrichum & Penicillium notatum by using agar diffusion assay and antimalarial activity against Plasmodium falciparum (Strain 3D7) using MTT assay. The results concluded that the compound R 1 exhibited significant antibacterial activity than R 2 against Gram-Negative bacteria with zones of inhibition ranging from 15-20 mm. and mild antibacterial activity against Gram-Positive bacteria in comparison to tetracycline, streptomycin and rifampicin. These complexes were found to have moderate antifungal activity with no activity was however observed against Aspergillus niger. The compound, R 1 exhibited antimalarial activity at 10 µg/mL, whereas R 2 did not show antimalarial activity upto 50 µg/mL. Sensitivity to the compounds was greatest in the gram-negative bacteria, followed by the grampositive bacteria and fungi.
In present study transdermal drug delivery of Physostigmine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Among all the formulations P6 formulation was found to be best and shown 96.5% drug release in 12 hours. For P6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release.
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