The efficiency of a molecularly imprinted polymer as a selective packing material for the solid-phase extraction of imatinib mesylate sorption was investigated. The molecularly imprinted polymer was prepared using N,N ′ -methylenebisacrylamide as a cross-linker agent, N-vinylcaprolactam as a thermo-sensitive monomer, 1-vinyl-2-pyrrolidone and methyl methacrylate as functional monomers, azobisisobutyronitrile as an initiator and imatinib mesylate as a template. The drug-imprinted polymer was identified by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. It was found that this polymer can be used for determination of trace levels of imatinib mesylate with a recovery percentage that could reach over 90%. Furthermore, the synthesized molecularly imprinted polymer indicated higher selectivity towards imatinib mesylate than other compounds. From isotherm study, the equilibrium adsorption data of imatinib mesylate by imprinted polymer were analyzed by Langmuir, Freundlich, and Temkin isotherm models. The developed method was used for determination of imatinib mesylate in human fluid samples by high performance liquid chromatography with excellent results.
K E Y W O R D Simatinib mesylate, molecularly imprinted polymer, thermosensitive polymer, selective extraction, human biological fluids 614
Nanoparticles (NPs) have gained more attention as drug delivery systems. Folic acid (FA)-chitosan (CS) conjugates, because of their biodegradability, low toxicity, and better stability, offer a pharmaceutical drug delivery tool. The aim of this work was to fabricate CuS NPs modified by CS followed by grafting FA as a nanocarrier for the delivery of cytarabine (CYT) as an anticancer drug. In this work, CuS NPs modified by CS and FA were successfully synthesized. The structural properties of the nanocarrier were characterized by using scanning electron microscopy, Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, and Brunauer-Emmett-Teller. The adsorption mechanism of CYT by adsorption isotherms, kinetics, and thermodynamics was deliberated and modeled. The in vitro CYT release behavior for the nanocarrier was 99% and 61% at pH 5.6 and 7.4, respectively. The adsorption behavior of CYT by CuS NP s -CS-FA was well explored by pseudo-second-order kinetic and Langmuir isotherm models by the coefficient of determination (R 2 > 0.99). Thermodynamic results showed that the uptake of CYT by CuS NPs-CS-FA was endothermic and spontaneous. The experimental results showed that CYT/CuS NP s -CS-FA can be proposed as an efficient nanocarrier for the targeted delivery of anticancer drugs.
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