NIR Laser Irradiation-Controlled Docetaxel Release from Nanodiamond Decorated with Temperature Stimuli Responsive Polymer Containing PAMAM Dendrimer

Asghari, Bita Mohammad; Zadeh, Marjaneh Samadi; Panahi, Homayon Ahmad; Tackallou, Saeed Hesami; Safaeijavan, Raheleh

doi:10.1007/s10924-023-02842-w

Cited by 3 publications

(2 citation statements)

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“…Recently, Safaeijavan's group demonstrated the use of a photothermal approach, where nearinfrared (NIR) light was converted into heat, to trigger the release of anticancer drugs from NDs. 26 In their study, NDs were coated with thermosensitive polymers conjugated to poly(amidoamine) dendrimers. However, the lack of spatial specificity and temporal control, as well as the potential damage to normal tissues, present challenges for the clinical applications of photothermal therapy.…”

Section: ■ Introductionmentioning

confidence: 99%

“…It offers instantaneous manipulation and enables remote control with a high spatiotemporal precision. Recently, Safaeijavan’s group demonstrated the use of a photothermal approach, where near-infrared (NIR) light was converted into heat, to trigger the release of anticancer drugs from NDs . In their study, NDs were coated with thermosensitive polymers conjugated to poly(amidoamine) dendrimers.…”

Section: Introductionmentioning

confidence: 99%

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Light-Activated Nanodiamond-Based Drug Delivery Systems for Spatiotemporal Release of Antisense Oligonucleotides

Leung,

Liu,

Cai

et al. 2024

Bioconjugate Chem.

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Nanodiamonds (NDs) are considered promising delivery platforms, but inaccurate and uncontrolled release of drugs at target sites is the biggest challenge of NDs in precision medicine. This study presents the development of phototriggerable NDbased drug delivery systems, utilizing ortho-nitrobenzyl (o-NB) molecules as photocleavable linkers between drugs and nanocarriers. UV irradiation specifically cleaved o-NB molecules and then was followed by releasing antisense oligonucleotides from ND-based carriers in both buffer and cellular environments. This ND system carried cell nonpermeable therapeutic agents for bypassing lysosomal trapping and degradation. The presence of fluorescent nitrogen-vacancy centers also allowed NDs to serve as biological probes for tracing in cells. We successfully demonstrated phototriggered release of antisense oligonucleotides from NDbased nanocarriers, reactivating their antisense functions. This highlights the potential of NDs, photocleavable linkers, and light stimuli to create advanced drug delivery systems for controlled drug release in disease therapy, opening possibilities for targeted and personalized treatments.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%