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Background: Increased levels of tumour markers: carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag), Alpha feto protein (AFP), and neuron-specific enolase (NSE) may indicate the onset of the carcinogenic process. The aminotransferases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are the most commonly measured enzymes that detect hepatocellular injury. Formaldehyde has an important application as a disinfectant and preservative, reason why relevant workplace exposure may also occur in pathology and anatomy laboratories and in mortuaries. Urinary thioethers are excretion products resulting from a series of metabolic reactions which involve oxidation of lipophilic chemicals to water-soluble compounds Objective: The aim of the present study was to evaluate of the hazardous effects of occupational exposure to formaledehyde among lab technicians through measuring liver enzymes, hepatic tumor marker (AFP, CEA) and levels of urinary thioether as indicator of exposure to Carcinogenic compounds. Method: the study was conducted on thirty male workers employed in medical pathology and anatomy teaching laboratories. Thirty subjects were recruited as a control group matched for age, sex and socioeconomic status. Results: the results revealed a high significant increase in the levels of urinary thioethers in exposed workers than those of control group and high significant elevation in the levels of tumors markers (CEA and AFP) in exposed workers in comparison with control group. Moreover, a significant increase in the levels of liver functions (AST and ALT) was observed in formaldehyde exposed workers. Conclusion: Present data indicate that formaldehyde exposed workers exhibit an increase in tumor markers levels and additionally increase in the levels of urinary thioethers. Safety Preventive measures should be applied for reduction of the formaldehyde vapors in these laboratories.

Workers reach into the oven, pull out the cured mold, and then file the mold to remove any residual molding compound. Finally, they stack the mold and then repeat the process. It takes approximately 30 seconds to remove, file, and stack each mold. The worker continually repeats the process over the work shift. Environmental conditions:A fine yellow-orange powder is created from filing of the molds. The worker wears mid-forearm heat resistant gloves.

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ObjectivesProfessional divers are exposed to unique multifactorial hazards in their working environment and cardiovascular effects are tremendous. Cardiovascular events are aggravated by diving-induced oxidative stress and account for one fourth of diving fatalities. The aim of this study was to assess the oxidative and cardiovascular stress in a group of professional divers in Alexandria, Egypt using a panel of biomarkers.MethodsA comparative cross-sectional study was conducted between June 2017 and May 2018 at the General Naval Hospital in Alexandria. We recruited 50 professional divers (n=50) and a comparison group of 50 marine seafarers sharing similar maritime environments. Participants were clinically evaluated by electrocardiography (ECG) and assessment of some trace metals (Fe+, Cu+and Zn+) and oxidative stress biomarkers (OSBMs; MDA, TAS, GST, GSH, GR, GPx, SOD and CAT).Results: Significant ECG abnormalities including short corrected QT interval, sinus bradycardia, left ventricular hypertrophy, early repolarization, 1stdegree heart block, intraventricular conduction defect were obvious among divers. The mean levels of FBG, LDH-C, Na+, Ca+, trace metals and OSBMs were significantly higher among professional divers compared to the marine seafarers (p< 0.5).ConclusionThe risk of CVD in professional divers is alarmingly high and possibly contributed by OS. Including cardiovascular risk assessment in divers’ periodic examinations is of utmost importance.