Abstract:Resveratrol is a natural substance that has been the target of many researchers over the years since it presents a variety of potential applications in the areas of cosmetics and medicine as a treatment for some diseases. Due to its high antioxidant capacity but low bioavailability, we evaluated the antiaging potential of resveratrol as a liotropic liquid crystal emulsion. Initially, we performed in vitro assays to quantify both the organoleptic characteristics and stability of the emulsion. Next, an in vivo trial was performed on the faces of 30 volunteers to determine the cream's cosmetic potential and to measure porphyrins, skin barrier function, skin pigmentation, expression lines, and porosity. The emulsion maintained its characteristics during the in vitro assays and, in the in vivo trial, it had some effect only on pore size in forehead, without any significant effects on the other parameters. We had 6 dropouts throughout the study, then the final number of volunteers was 24. Most volunteers did not show any changes in skin pigmentation throughout the study. Similarly, there was not any noticeable improvement on any other parameters evaluated. However, volunteers related a high level of satisfaction with the product.
A candidíase oral é a infecção fúngica mais comum na cavidade oral humana, devido ao potencial de resistência aos antifúngicos e seus efeitos colaterais, desta forma a aplicação de novos tratamentos são necessários. A terapia fotodinâmica (PDT) têm demonstrado bons resultados no controle e tratamento da candidíase oral. O objetivo deste estudo foi apresentar a importância da PDT no tratamento da candidíase oral. Método: Revisão de literatura narrativa, com base nas bases de dados MedLine, PubMed, Scielo, Google acadêmico e Lilacs. Foram pesquisados livros, artigos científicos, monografias, teses e dissertações publicados entre 2011 e 2022. Os resultados mostraram que a PDT sozinha possui potencial para controlar satisfatoriamente a candidíase oral, mas os melhores resultados efetivos foram obtidos com a PDT associada aos cuidados de higiene oral habituais.
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