Cosmetic Potential of a Liotropic Liquid Crystal Emulsion Containing Resveratrol

Abstract

Abstract:Resveratrol is a natural substance that has been the target of many researchers over the years since it presents a variety of potential applications in the areas of cosmetics and medicine as a treatment for some diseases. Due to its high antioxidant capacity but low bioavailability, we evaluated the antiaging potential of resveratrol as a liotropic liquid crystal emulsion. Initially, we performed in vitro assays to quantify both the organoleptic characteristics and stability of the emulsion. Next, an in vivo trial was performed on the faces of 30 volunteers to determine the cream's cosmetic potential and to measure porphyrins, skin barrier function, skin pigmentation, expression lines, and porosity. The emulsion maintained its characteristics during the in vitro assays and, in the in vivo trial, it had some effect only on pore size in forehead, without any significant effects on the other parameters. We had 6 dropouts throughout the study, then the final number of volunteers was 24. Most volunteers did not show any changes in skin pigmentation throughout the study. Similarly, there was not any noticeable improvement on any other parameters evaluated. However, volunteers related a high level of satisfaction with the product.

Formulation and Evaluation of Liquid Crystal Emulsion Containing Extra Virgin Olive Oil as Skin Anti-Aging

“…This is because the surfactants that used in the EVOO liquid crystal emulsion (alkyl polyglycosides and caprylic triglycerides) are forming a lamellar liquid crystal structure. The structure of the lamellar liquid crystal is very dependent on the structure of the alkyl polyglycoside [4,15]. The liquid crystal phase has some characteristics like solid and more organized like liquid, characterized by the ability to flow [16], it made the emulsions to be stable.…”

“…Skin aging occurs just like the aging of body cells in general, which is the accumulation of endogenous damage due to the formation of Reactive Oxygen Species (ROS) during cellular oxidation metabolism [3]. ROS causes oxidative stress on biological structures, which ultimately has an impact on physical appearance and biochemical changes causing phenotypic consequences such as expression lines, low hydration, and pigmentation [4].…”

Resveratrol as a factor preventing skin aging and affecting its regeneration

“…The compound, however, does not affect 5α-dihy-drotestosterone, 5α-reductase or oestrogen-related gamma receptor without participating in the production of collagen associated with the change in the concentration of these compounds (this happens due to the action on the oestrogen-related α receptor and oestrogen-related β receptor) [ 11 , 12 ]. Polyphenol inhibits tyrosinase, reducing skin discoloration and smoothes wrinkles through activity against granulocyte-macrophage colony-stimulating factor (GM-CSF) and matrix metalloproteinase 1 (MMP-1) [ 13 – 16 ].…”

“…In some of the patients, pigmentation increased (4 people – the forehead, 5 people – the buccal area). It was found that the cream had no significant effect on wrinkle reduction and water retention, preventing dry skin [ 11 ].…”