The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past decade. Currently, there are multiple alternatives available as suitable treatments; however, the use of autologous blood-derived products such as platelet-rich plasma (PRP), bone marrow aspirate (BMA) and BMA concentrate (BMAC), specifically, is expanding. Although many investigations attempted to demonstrate the effectiveness of these therapies, even with positive results, the literature lacks standardized protocols and overall accuracy in study designs, which leads to variance and difficulty in reproducibility of protocols. The efficacy of PRP for the treatment of cartilage, bone and muscle tissues is well known. Although BMAC has generated optimistic results for the same purposes, its applicability in clinical trials is still relatively recent when compared to PRP. Both products demonstrate the potential to set forth reparative processes, each in their own distinct mechanism. The combination of these biological products has been previously proposed, yet little is known about their synergism. Evidence indicates that growth factor, cytokine, and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal healing. BMAC products seem to work well without PRP; however, the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow itself. Nevertheless, additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.
Abstract. In order to ensure dignity to people, it is essential that their rights are attended even with their different limitations and challenges. The use of new communication and information technologies (ICT) allows IntroduçãoAtravés de estudos como os vistos em Santana e outros (2016) e Oliveira e Leite (2007), é possível verificar os desafios ainda presentes na educação especial. Os professores ainda não estão capacitados o suficiente para difundir o conhecimento de maneira efetiva para pessoas com algum tipo de deficiência, fazendo com que o conhecimento não seja acessível para todos. Outra questão, tão importante quanto à formação docente, é a falta de recursos adaptados e apropriados para as necessidades próprias de cada tipo
Introduction: Chronic postoperative pain, defined as persistent pain at the surgical incision site 3 months after a procedure, is a common complaint in orthopedic practice. Almost 50% of patients who undergo orthopedic surgery are presumably affected by this complaint. The objective of this study is to evaluate the lidocaine patch 5% as a method for neuropathic pain treatment after orthopedic surgery compared with therapeutic massage performed over the incisions. Methods: This is a prospective, randomized clinical trial of 37 patients who underwent orthopedic surgery from January 2015 to February 2017. All individuals were assessed using the pain visual analog scale (VAS) and the 36-Item Short Form Survey (SF-36) quality of life questionnaire at treatment onset and at 30, 60 and 90 days of treatment. Results: Both groups showed improvement in pain, although the group using the patch showed a greater reduction of pain over time. There were no significant differences in the parameters assessed by the SF-36: physical functioning, physical role functioning, vitality, emotional role functioning, social role functioning, general health perceptions or mental health. The main advantage of the patch lay in the degree of patient satisfaction, which was significantly higher than that of massage, most likely because the patch is easily applied and generates a psychological effect as a drug therapy. Conclusion: The lidocaine patch and massage are effective treatment methods for reducing scar pain that show similar results. The patch is associated with an improvement in the degree of patient satisfaction.
Introduction: Foot extensor tendon injuries account for 1% of all tendon injuries. Extensor hallucis longus (EHL) tendon lacerations are even less common, and studies on the subject are limited to a small number of case reports and series. Objective: The objective of this report is to show the possibility of using the plantaris muscle as a graft option for the reconstruction of the extensor hallucis longus tendon in cases of damage due to chronic injury. Methods: The subject was a 30-year-old male factory worker who had had a laceration in the dorsal region of the right foot for approximately 2 months. He showed a deficit in hallux extension. Given the indication for surgical treatment and due to the distances between the stumps, we chose to use the plantaris muscle as a graft. Results: The patient was evaluated 6 months after surgery, and we observed a satisfactory outcome with improvements in hallux extension and functional gait. Conclusion: We chose the plantaris tendon as a graft because we believe it is easily harvested, has low morbidity at the donor site, has no or minimal loss of function and meets the needs for the desired reconstruction. Because this is a large graft, we solved the problem of the smaller diameter by performing double-band reconstruction. We concluded that the plantaris is a viable option for neglected EHL injuries or rerupture that offers low morbidity with no significant loss of function in the donor region.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.