Introduction: Late acute rejection leads to worse patient and graft survival after liver
transplantation. Aim: To analyze the reported results published in recent years by leading transplant
centers in evaluating late acute rejection and update the clinical manifestations,
diagnosis and treatment of liver transplantation. Method: Systematic literature review through Medline-PubMed database with headings related
to late acute rejection in articles published until November 2013 was done. Were
analyzed demographics, immunosuppression, rejection, infection and graft and
patient survival rates. Results: Late acute rejection in liver transplantation showed poor results mainly regarding
patient and graft survival. Almost all of these cohort studies were retrospective
and descriptive. The incidence of late acute rejection varied from 7-40% in these
studies. Late acute rejection was one cause for graft loss and resulted in
different outcomes with worse patient and graft survival after liver transplant.
Late acute rejection has been variably defined and may be a cause of chronic
rejection with worse prognosis. Late acute rejection occurs during a period in
which the goal is to maintain lower immunosuppression after liver transplantation.
Conclusion: The current articles show the importance of late acute rejection. The real benefit
is based on early diagnosis and adequate treatment at the onset until late follow
up after liver transplantation.
Background: Liver transplantation is the main treatment for hepatocellular carcinoma (HCC). However, because of the limited supply of transplant organs, it is necessary to adopt a criterion that selects patients who will achieve adequate survival after transplantation. The aim of this review is to compare the two main staging criteria of HCC for the indication of liver transplantation (Milan and UCSF) and to analyze the posttransplantation survival rate at 1, 3 and 5 years.Methods: This is a systematic review and meta-analysis in which scientific articles from 5 databases (PubMed, Lilacs, Embase, Central, and Cinahl) were analyzed. The studies included in the review consisted of liver transplantation in patients with HCC in different subgroups according to donor type (deceased × living), population (eastern × western) and tumor evaluation (radiological × pathological) and adopted the Milan or UCSF criteria for the indication of the procedure.
Drug reaction with eosinophilia and systemic symptoms is a quite unusual condition related to drug reaction. A case report of sulfasalazine-induced liver failure is described. The patient was submitted to liver transplantation. Liver transplantation is an option when DRESS is associated with acute liver failure, but the prognosis remains poor.
KEY CLINICAL MESSAGEThis study describes a patient with drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), associated with liver failure.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.