Liver transplantation after DRESS syndrome: a case report and review of the literature

Abstract

Drug reaction with eosinophilia and systemic symptoms is a quite unusual condition related to drug reaction. A case report of sulfasalazine-induced liver failure is described. The patient was submitted to liver transplantation. Liver transplantation is an option when DRESS is associated with acute liver failure, but the prognosis remains poor. KEY CLINICAL MESSAGEThis study describes a patient with drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), associated with liver failure.

Identification of novel signal of clobazam‐associated drug reaction with eosinophilia and systemic symptoms syndrome: A disproportionality analysis

“…The level of liver enzymes significantly increased in DRESS syndrome 10 . The life‐threatening effects of DRESS syndrome on liver are also observed as reported recently by Calil et al; 11 however, these effects are quite rare. Recently, Gómez et al 12 have reported the severe and atypical lung involvement with DRESS syndrome.…”

La complessità della diagnosi di una sindrome da reazione a farmaco nel bambino

“…Il trattamento cardine è rappresentato dai corticosteroidi sistemici (dose iniziale di prednisolone o equivalente di 0,5-1,0 mg/kg/die) con un graduale décalage nell'arco di minimo 2-3 mesi al fine di ridurre la probabilità di riacutizzazioni della malattia. L'epatopatia nella sindrome DRESS, quando presente, ha una variabile risposta al trattamento steroideo, da forme rapidamente responsive a epatopatie resistenti per le quali si rende necessario il ricorso al trapianto di fegato [10]. Nel nostro caso si è scelto di prolungare il trattamento a basse dosi fino a completa normalizzazione delle transaminasi.…”

Atypical, Levetiracetam-induced Hypersensitivity Syndrome Complicated by Fulminant Liver Failure in a Patient Undergoing Hemodialysis

“…Aggressive treatment may be required in severe liver failure; however, a treatment strategy for this situation has not yet been established (9). Although few patients undergo liver transplantation, the prognosis of this syndrome is poor, with a relatively high mortality rate (approximately 50%) (10). Furthermore, a case of fulminant liver failure due to recurrence of DRESS following liver transplantation has been reported (11).…”