The significantly higher prevalence of CD in children with type 1 diabetes, in accordance with the large volume of data published in the literature, underlines the need for yearly screening of CD in patients with diabetes in order to promptly start a gluten-free diet when appropriate.
The identification of microorganisms by multiplex PCR is specific and sensitive. Rapid and precise assessment of different types of periodontopathogens is extremely important for early detection of the infection and consequently for the prevention and treatment of periodontal disease. In everyday clinical practice, for routine bacterial evaluation in patients with periodontal disease, the dental plaque is the most suitable biological material, because it is the richest in periodontal bacteria.
Antovic J, Bakic M, Milicevic R, Gojkovic G, Blomback M. Activation of the coagulation system occurs within rather than outside cutaneous haemangiomas. Acta Paediatr 2001; 90: 1137-1140 Haemangiomas are the commonest tumours of infancy. They can become even more serious if followed by consumption coagulopathy and even life-threatening in cases of Kasabach-Merritt syndrome, with thrombocytopeni a and haemorrhage. Data exist concerning systemic coagulation abnormalities in children with haemangiomas but to our knowledge there are no data on local consumption coagulopathy in haemangioma per se. We examined blood coagulation and brinolysis parameters in blood withdrawn from haemangioma blood vessels and blood withdrawn from the systemic vein in 14 children with cutaneous haemangiomas (3M, 11F; age range 3 mo to 10 y). Compared with controls, signi cant decreases in brinogen levels, FVII activity, antithrombin and plasmin inhibitor levels and increases in international normalized ratio (INR) and D-dimer levels were observed in the blood samples withdrawn directly from haemangioma blood vessels. Fibrinogen and antithrombin levels in samples withdrawn from systemic veins were reduced in relation to control values whilst INR values increased, but within normal ranges. D-dimer levels were increased in peripheral blood. The brinogen level was signi cantly lower and the INR and D-dimer levels were signi cantly higher in blood samples from haemangiomas compared to systemic blood. Clinical signs of systemic disseminated intravascular coagulation were not observed. Conclusions:Our results suggest a strong local activation and local consumption coagulopathy in haemangioma, along with less conspicuous but observable systemic changes in coagulation and brinolysis parameters, although without signs of consumptive coagulopathy. These systemic changes could be a re ection of intra-lesion coagulation activation although there is no evidence to suggest truly systemic disseminated intravascular coagulation.
Congenital anomalies are the cause of prenatal death in 20-25% of the cases, while 3% of children are born with a malformation of varying size. Many of these anomalies can be detected before birth using different non-invasive and invasive prenatal diagnostic tests. This study was used to determine the distribution of genetic disorders in relation to the age of the mother, the frequency of aberrations and to study the effects and importance of prenatal diagnosis in South Serbia. Prenatal diagnostics was performed at the Pediatric Clinic within the Clinical Center of Niš. This retrospective study included a group of 8830 pregnant women, aged between 18 and 47 years during the period from 2004 to 2017. Amniocentesis was performed between the 16 th and 18 th week of pregnancy and involved the aspiration of 20 ml of amniotic fluid. Isolated cells were cultured in a medium that stimulates cell growth for 10 days. After cytogenetic processing, the obtained karyotype was analyzed using G-banding techniques. In 8830 samples of amniotic fluid cell cultures, 198 karyotypes with chromosomal aberrations were found-179 with numerical aberrations and 19 with structural aberrations such as translocations, inversions and deletions. There were 85 karyotypes with autosomal numerical aberrations and 32 karyotypes with sex chromosome numerical aberrations. The most frequent one was trisomy 21 (106 cases). The highest number of autosomal numerical aberrations, 158
Kratak sadr`aj: Tokom inflamacije dolazi do aktivacije endotela i ispoljavanja njegove proadherentne sposobnosti. Sinteza reaktivnih metabolita kiseonika koja prati imunolo{ke procese mo`e pokrenuti oksidativno o{te}enje mikrovaskularnih endotelnih }elija, {to se klini~ki manifestuje pojavom razli~itih ko`nih manifestacija. U radu je pra}ena aktivnost antioksidativnih enzima (superoksid-dizmutaza, kata laza, glutation-peroksidaza) kao i vrednosti malondialde hida kod 36 dece sa inflamatornim o{te}enjem endotelnih }elija. Na osnovu prisutnih klini~kih manifestacija ispitanici su podeljeni u 4 grupe (I grupa-makulozne promene na ko`i, II grupa-makulo-papulozne, III grupa-papulozne i IV grupa-eritematozne promene na ko`i). Svi paci jen ti su pre ispoljavanja manifestacija na ko`i imali simp tome inflama cije (uglavnom infekcije respiratornih puteva) i kod svih su u krvnoj slici registrovane leukocitoza i monocitoza. U tri grupe ispitanika aktivnost superoksid--diz mutaze bila je zna~ajno sni`ena, sem u grupi ispitanika sa eritematoznim promenama na ko`i, dok je aktivnost kata laze u svim ispiti vanim grupama bila zna~ajno povi{ena u odnosu na vred no sti u kontrolnoj grupi. Vrednosti malondial dehida bile su zna~ajno povi{ene u grupi dece sa makulopapuloznim i eritematoznim ko`nim promenama. Dobijeni rezultati po tvr|uju prisustvo oksidativnog stresa tokom inflamatornog o{te}enja endotelnih }elija, ali se malon dialdehid, kao parametar lipidne peroksidacije, nije pokazao adekvatnim za procenu inflamatornog endotelnog o{te}enja.
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