SummaryOsteoporosis is a systemic skeletal disease characterized by decreased bone mass, destruction of the microarchitectonics of bone structure and a high risk for fracture. One of the criteria for altered bone homeostasis includes the changes in serum levels of alkaline phosphatase (ALP) and the activity of matrix metalloproteinases (MMPs). The purpose of this study was to determine the serum concentrations of calcium (Ca 2+ ), phosphorus (P), magnesium (Mg 2+ ), alkaline phosphatase (ALP) and MMP-9 in ovariectomized rats. We used 35 female Wistar rats at reproductive age (2 months) divided into 2 groups: a control group (G1-SHAM) -20 animals subjected to "false" ovariectomy and placebooperation, and an ovariectomized group (G2-OVX) -15 animals subjected to bilateral ovariectomy. Blood was collected from the abdominal aorta for testing levels of Ca 2 + , P, Mg 2+, ALP and MMP-9. No statistically signi cant differences in serum concentrations of 2+ , P and Mg 2+were found between G2 and G1 ( >0.05). The values of ALP and MMP-9 in rats of G2 were statistically signi cantly increased, as compared to G1 (p<0.05). The serum activity of ALP, which is a marker for bone formation, was increased in OVX-induced osteoporosis. Elevated serum MMP-9 levels in G2 con rmed the hypothesis that it is a marker for osteoclast activity.

SummaryDesmoid-type bromatosis is a rare mesenchymal neoplasm with locally aggressive, in ltrating and destructive growth that is not characterized by a metastatic potential. According to their anatomical position, desmoid-type bromatoses can be divided into three groups: extraabdominal, intra-abdominal, and bromatoses of the abdominal wall. Mesenteric bromatoses account for 8% of the intra-abdominal ones. The latter are characterized by myo broblastic proliferation and in ltration of both the pelvic and abdominal organs. We report a 26-year-old woman who complained of abdominal enlargement, feeling of heaviness, discomfort and re ux, which symptoms dated back 1-2 months prior to hospitalization. The patient underwent laparotomy due to subocclusive symptoms. Intraoperatively, a tumor sized 30 cm in diameter was found. The tumor originated from the mesentery and in ltrated in the jejunum, the entire ileum, and part of the caecum with perforation towards the abdominal cavity. The histological and immun histochemical examinations are important for clari cation of the diagnosis. The treatment requires a multidisciplinary approach, in which the surgical method has the key role.

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