New Findings r What is the central question of this study?The acute effect of exercise at moderately high intensity on already-elevated pulmonary arterial pressures and right ventricular wall stress in a rat model of pulmonary arterial hypertension (PAH) is unknown. r What is the main finding and its importance?We show, for the first time, that in a rat model of PAH, exercise induces an acute reduction in pulmonary artery pressure associated with lung endothelial nitric oxide synthase activation, without evidence of acute right ventricular inflammation or myocyte apoptosis. Haemodynamic measures obtained with traditional invasive methodology as well as novel implantable telemetry reveal an exercise-induced 'window' of pulmonary hypertension alleviation, supporting future investigations of individualized exercise as therapy in PAH.Exercise improves outcomes of multiple chronic conditions, but controversial results, including increased pulmonary artery (PA) pressure, have prevented its routine implementation in pulmonary arterial hypertension (PAH), an incurable disease that drastically reduces exercise tolerance. Individualized, optimized exercise prescription for PAH requires a better understanding of disease-specific exercise responses. We investigated the acute impact of exercise on already-elevated PA pressure and right ventricular (RV) wall stress and inflammation in a rat model of PAH (PAH group, n = 12) induced once by monocrotaline (50 mg kg −1 , i.p.; 2 weeks), compared with healthy control animals (n = 8). Single bouts of exercise consisted of a 45 min treadmill run at 75% of individually determined aerobic capacity (V O 2 max ). Immediately after exercise, measurements of RV systolic pressure and systemic pressure were made via jugular and carotid cannulation, and were followed by tissue collection. Monocrotaline induced moderate PAH, evidenced by RV hypertrophy, decreasedV O 2 max , PA muscularization, and RV and skeletal muscle cytoplasmic glycolysis detected by increased expression of glucose transporter-1. Acute exercise normalized the monocrotaline-induced elevation in RV systolic pressure and augmented pulmonary endothelial nitric oxide synthase activation, without evidence of increased RV inflammation or apoptosis. Real-time recordings of pulmonary and systemic pressures during and after single bouts of exercise made using novel implantable telemetry in the same animal for up to 11 weeks after monocrotaline (40 mg kg −1 ) corroborated the finding of acute PA
The aim of the present study is to determine whether 2 current admission criteria, the perceptual ability test (PAT) and the manual dexterity test (MDT) can predict success in dental school within the Université de Montréal population. Methods: A retrospective cohort study was conducted using the records of 854 students who graduated between 2005 and 2015. For each student, PAT and MDT scores were compared to 5 preclinical and 3 clinical classes using the Pearson correlation coefficient and regression models. T-tests were used to compare students above and below a 5-point increase in cutoff scores (PAT = 15, MDT = 10). Results: The strongest relationship was found to be between PAT and preclinical scores (r = 0.329, P < 0.01). The regression analysis determined that gender, PAT and MDT predicted more of the variability of preclinical (12.7%) than of clinical scores (2.7%). Students scoring ≥10 on the MDT performed better in preclinical and clinical courses, and those scoring ≥15 on the PAT performed better in preclinical courses. However, when comparing these students to the entire group, only those scoring ≥15 on PAT differed from the group's average for preclinical scores (P = 0.029). Conclusion: These findings suggest the PAT and MDT have some power in predicting success in preclinical, and to a lesser extent clinical courses, and supports their use as criteria in the admissions process. There is some evidence that suggests that increasing the cutoff score may decrease the number of students with difficulties in preclinical courses.
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