The antifungal activity of methanolic crude extracts of Acorus calamus, Tinospora cordifolia and Celestrus paniculatus was investigated against Alternaria solani, Curvularia lunata, Fusarium sp., Bipolaris sp. and Helminthosporium sp. at different concentrations (1000, 2000, 3000, 4000 and 5000 mg/ml). At 5000 mg/ml, crude extract of T. cordifolia is found to be highly effective against Helminthosporium sp. followed by A. calamus against A. solani. On the other hand, at 5000 mg/ml, C. paniculatus showed better activity against A. solani and Helminthosporium followed by A. calamus against A. solani at 4000 mg/ml. At 5000 mg/ml, all the three crude extracts showed least activity against fungus C. lunata and Fusarium sp. except A. calamus that showed better activity against C. lunata. The increase in the production of phenolic acid in the extract can be correlated with the induction of resistance in treated plants against phytopathogenic fungi. High-performance liquid chromatography analysis of the crude extract of medicinal plants showed six different phenolic acids (benzoic acid, cinnamic acid, caffeic acid, ferulic acid, gallic acid and tannic acid) present in varying amounts. The results of the study provide scientific basis for the use of the plant extract in the future development as antioxidant, antibacterial, antifungal and anti-inflammatory agent.
Changes in lifestyle including dietary changes and reduced physical activity due to mechanization are contributing to the development of heart diseases. The use of drugs like statin for long term has led to serious side effects and reduced HDL-C synthesis. In view of these facts we planned the present study to evaluate the hypolipidemic potential of Emblica officinalis (amla) powder and nutrition counselling in hyperlipidemic subjects. 60 volunteer male hyperlipidemic subjects having total cholesterol > 200mg/dl, aging 39-49 years were selected from PAU Hospital and information regarding their background, lifestyle and medical family history was collected. Subjects were divided into 2 groups experimental E and control C. Experimental group was supplemented with 5g E. officinalis powder and nutrition counselling and C was given nutrition counselling only for 90 days. A significant reduction in cereal, fats and oil and sugar and jaggery intake and an increase in intake of pulses, fruits, other vegetables, roots and tubers and milk was observed. Serum total cholesterol, LDL-C, triglycerides and VLDL-C in group E were significantly reduced after the study when compared with group C. An impressive 8.19 percent increase in HDL-C in the subjects of group E was observed. Therefore, supplementation of E officinalis (amla) powder and nutrition counselling can be an effective strategic dietary intervention for controlling serum lipid profile in hyperlipidemic subjects.
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