EMPF should be considered as a differential diagnosis for adult horses with interstitial pneumonia and should be suspected on the basis of characteristic radiographic, ultrasonographic, and histopathologic findings. Equine herpesvirus type 5 is found in association with EMPF; although the exact pathogenic role this virus plays in EMPF is unknown, equine herpesvirus type 5 may be an etiologic agent or cofactor in the development of EMPF.

Orbital infection with Aspergillus fumigatus was diagnosed in a Persian cat that was presented with chronic third eyelid protrusion and exophthalmos. Evidence of nasal, sinus, or disseminated aspergillosis was not detected in this cat. Complete surgical excision of diseased tissues was not possible during orbital exenteration, and infection subsequently extended into the tissues of the oral cavity. Oral therapy with itraconazole and parenteral therapy with amphotericin B were ineffective in resolving the infection. Oral therapy with a novel triazole, posaconazole, was curative.

Abstract.A 10-year-old terrier crossbreed presented with a change in bark intonation of 3-4 month's duration and pronounced panting. Four variably sized masses were observed within the oral cavity. The largest mass was located within the parenchyma at the caudal region of the tongue. Others were located on the left arytenoid, within the soft palate, and in the oropharynx above the soft palate. Histopathologic specimens consisted of large round to polygonal cells occasionally containing multiple nuclei and rare faint cytoplasmic cross striations. Staining was weakly positive with periodic acid-Schiff. Immunocytochemistry was strongly diffusely positive for muscle-specific actin, myoglobin, and desmin and scattered positive for S-100 and vimentin. Phosphotungstic acid-hematoxylin staining enhanced cytoplasmic cross striations. The cytoplasm of all neoplastic cells was filled with mitochondria on electron microscopy. The final diagnosis was multifocal/metastatic rhabdomyosarcoma.Key words: Dogs; multifocal rhabdomyosarcoma; nasopharynx; oral cavity; tongue.A 10-year-old crossbreed, spayed female terrier presented to Avondale Animal Hospital with a change in bark intonation of 3-4 month's duration and pronounced panting. Four variably sized masses were observed within the oral cavity. The largest mass was located within the muscle parenchyma at the caudal region of the tongue. Others were found on the left arytenoid, within the soft palate, and within the nasopharynx above the soft palate. Fine-needle aspirates from the tongue and arytenoid masses were submitted, stained with Wright's stain, and examined microscopically. The four specimens contained similar polygonal cells consisting of a round, vesicular nucleus with a prominent nucleolus often with anisonucleoliosis. The cytoplasm was abundant, containing numerous minute reddish granules. Moderate to marked anisocytosis and anisokaryosis were present. Multinucleated cells also were observed frequently. Granular cell tumor, oncocytoma, rhabdomyoma, or rhabdomyosarcoma were considered cytologically, with the granular cell tumor most likely due to location; however, because of the unusual multifocal or metastatic nature of the neoplasm, rhabdomyosarcoma also was considered.The dog was then referred to the Iowa State University veterinary teaching hospital. The dog appeared healthy without dyspnea. Hematologic and serum biochemical parameters were within the established reference values. On urinalysis, a 4ϩ proteinuria was present, with a urine protein-creatinine ratio of 4.21. Blood pressure was elevated at 208 mm Hg. Increased blood pressure and proteinuria findings were not associated with the oral masses.Surgical removal of the four masses was attempted. After debulking of the masses, laser treatment was performed to cauterize the surrounding regions that could not be removed. Tissue specimens were fixed in 10% buffered formalin for histopathology and also in glutaraldehyde for electron microscopy (EM). Formalin-fixed tissues were prepared and initially stained wi...

A 7-year-old-spayed female standard poodle dog presented to the Iowa State University Veterinary Teaching Hospital with an 8-day history of lethargy, left hind limb lameness, ptyalism and peripheral lymphadenomegaly. On physical examination, the dog was lethargic, febrile (40.5 degrees C) and had multifocal to coalescing erythematous papular to pustular eruptions on the skin of all four limbs, periocularly and on the ventral and lateral thorax and abdomen. Histopathological findings from skin biopsies of the papules revealed a severe diffuse neutrophilic dermatitis with sub- and intra-epithelial pustules. Four days after being admitted the dog died from cardiac and respiratory failure. At necropsy, in addition to the multifocal to coalescing erythematous papules, the skin contained scattered pustules. Additionally, the subcutaneous tissue surrounding the right stifle was diffusely oedematous, and the peripheral and visceral lymph nodes were enlarged. The predominant histologic lesion was neutrophilic inflammation, in the absence of detectable bacteria in the skin, heart, lungs, oesophagus and left tarsus. In the absence of neoplasia or bacteraemia, a syndrome similar to Sweet's Syndrome should be considered as a differential diagnosis in dogs with cutaneous and extracutaneous neutrophilic infiltrates.

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