As expanded understanding of molecular tumor characteristics, which drive renal cancer growth and progression gives a promising future for renal carcinoma therapy. The objective of the present study was designed to examine the effect of β-sitosterol on a rat model of experimental renal carcinogenesis. Renal carcinogenesis was induced in rats treated with N-diethylnitrosamine (DEN; 200 mg/kg bw single i.p., injection) and ferric nitrilotriacetate (Fe-NTA; 9 mg Fe/kg bw i.p., twice a week for 16 weeks). β-sitosterol pretreatment (20 mg/kg bw in 0.1 % carboxymethyl cellulose (CMC) p.o., thrice a week for 24 weeks) was started 2 weeks before the exposure to carcinogens. Expression of angiogenesis marker (VEGF), proliferative markers (cyclin D1, PCNA) and apoptotic markers (Bcl-2, Bax, caspase-3 and caspase-9) were analyzed to assess the anti-cancer potential of β-sitosterol in renal carcinogenesis model. mRNA and protein expression changes were determined by qRT-PCR, Western blotting, ELISA technique and immunohistochemistry. Our results showed that oral administration of β-sitosterol pretreatment significantly ( < 0.05) reversed the expression of all the above mentioned markers and histological features which have been modified by renal carcinogen. It is concluded that, the protective effects of β-sitosterol against renal cancer is associated with the induction of apoptosis and the inhibition of cellular proliferation.
Administration of β-sitosterol to nephrotoxicity induced rats showed significant positive changes in biochemical parameters, histopathological and immunohistochemical observations, and up-regulation of Nrf2 gene expression. From this, it was clear that β-sitosterol showed renal protective function.
Pregnancy is a curious rousing and as frequently as possible upbeat hour in a woman's life, as spots of interest the woman's bewildering innovative and headway capacity while allowing a relationship with what's to come. There is a wide range of techniques for labour. Vaginal delivery is one of the most widely recognized and most secure sorts of labour. At the point when vital in specific conditions, forceps and vacuum delivery might be utilized. Now cesarean delivery is fundamental for the most secure of mother and child. The cesarean segment is the most every now and again performed a medical procedure on the planet. The point of the Study is to the adequacy of Hand and Foot Massage on Post cesarean pain among postnatal moms. Exploration approach utilized for the investigation was the quantitative methodology. The examination configuration was semi trial plan (pretest and post test control group). A complete of 60 members were choosing with non - likelihood purposive inspecting procedure was utilized and factual strategy applied for the investigation. The investigation was directed in a government hospital at Thiruvallur. The mean pre-test score in the exploratory gathering was 6.4 and meant the post-test score was 3.5. The 't' esteem is 33.72, which was huge at p≤0.05 level. Subsequently, it demonstrated that Hand and Foot Massage was viable in diminishing pain among post-cesarean moms in the experimental group.
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