In this contribution, ethanolic extracts of Cuminum cyminum (C. cyminum) seeds were evaluated in terms of phytochemical content, total phenol and flavonoid contents. As far as the analytical techniques are concerned, UV-Vis, FTIR, HPLC, NMR (1H and 13 C), and ESI-MS were performed.The binding capacity of five different antidiabetic enzymes were tested by in silico molecular docking studies. The HPLC, UV-Vis, FTIR, NMR, and ESI-MS data highlighted the presence of seven biologically active molecules e,g, α-Pinene, β-Pinene, ∆ 3 -Carene, ρ-Cymene, α-Terpineol, Cuminaldehyde, and Linalool. The results coming from the in silico molecular docking studies showed that such phytochemicals present in the cumin seeds extracts play an important role in the activity of key enzymes involved in carbohydrate metabolism. Therefore, C. cyminum is proven to be useful for the treatment of diabetes mellitus and its major secondary complications.
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