Phytochemical screening of ethanolic extracts of Cuminum cyminum L. seeds along with the evaluation of antidiabetic properties by molecular docking approach

Abstract

In this contribution, ethanolic extracts of Cuminum cyminum (C. cyminum) seeds were evaluated in terms of phytochemical content, total phenol and flavonoid contents. As far as the analytical techniques are concerned, UV-Vis, FTIR, HPLC, NMR (1H and 13 C), and ESI-MS were performed.The binding capacity of five different antidiabetic enzymes were tested by in silico molecular docking studies. The HPLC, UV-Vis, FTIR, NMR, and ESI-MS data highlighted the presence of seven biologically active molecules e,g, α-Pinene, β-Pinene, ∆ 3 -Carene, ρ-Cymene, α-Terpineol, Cuminaldehyde, and Linalool. The results coming from the in silico molecular docking studies showed that such phytochemicals present in the cumin seeds extracts play an important role in the activity of key enzymes involved in carbohydrate metabolism. Therefore, C. cyminum is proven to be useful for the treatment of diabetes mellitus and its major secondary complications.

Health Benefits of Cumin in Foods: A Review

“…In terms of gene expression, they observed signifi cantly decrease regulation of brain TKr A in the diabetic neuropathy group in comparison with healthy controls, associated by increase regulation for nerve growth factor therefore numerous treatments for diabetic neuropathy signifi cantly enhanced all biomarkers researched [31]. However, green synthesis of silver nanoparticles along with cumin extract may be a potential neuroprotective substance against infl ammation and oxidative stress, which characterizes diabetic neuropathy by antidiabetic, anti-infl ammatory, and antioxidant properties [44].…”

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

“…The cumin seeds have a strong taste that has been utilized as a food spice by many nations. Phytochemical analysis revealed several chemicals as main constituents of cumin seeds including γ‐terpinene, ρ‐cymene, β‐pinene, and cuminaldehyde (4‐isopropylbenzaldehyde); these compounds were associated with numerous biological potentials 17,18 . Cumin ( Cuminum cyminum ) is well‐document as rich source of terpenes, phenolic, and flavonoids 19 .…”

“…Phytochemical analysis revealed several chemicals as main constituents of cumin seeds including γ‐terpinene, ρ‐cymene, β‐pinene, and cuminaldehyde (4‐isopropylbenzaldehyde); these compounds were associated with numerous biological potentials. 17 , 18 Cumin ( Cuminum cyminum ) is well‐document as rich source of terpenes, phenolic, and flavonoids. 19 Nonetheless, Umbelliferae family has shown a variety of chemical compounds bearing some important bioactivities.…”

Biological activity of some phenolic compounds extracted from Agrimonia eupatoria against several pathogenic bacteria species

“…These compounds are natural products that are not directly on the basic function of plant life but important for plant survival or protection against other living organisms (Mishra and Tiwari 2011;Kumar et al 2015). There are a lot of studies on plant's natural products (Putra et al 2020;Hisham et al 2022;Lakshmanan et al 2022) Antibiotics have been essential in treating diseases caused by pathogenic microbes and have increased average life expectancy (Owusu et al 2021). In addition, antibiotics have a considerable positive influence on society, including a decrease in the number of people exposed to bacterial infections and people dying from infection, especially in underdeveloped nations with weak public health systems (Subramani et al 2017).…”

“…It resulted in producing various plant extracts and compounds effective against pathogenic microorganisms. Compared to synthetically synthesized compounds, compounds isolated from plants have lower adverse effects and are efficient against many bacteria due to their structural diversity (Muruzović et al 2016;Lakshmanan et al 2022). Plants can produce infinite compounds, including phenolic compounds, fatty acids, alkaloids, volatile oils, glycosides, tannins, and terpenes (Ginovyan et al 2017;.…”