The objective of this assay was to investigate the effect of adding sunflower oil, Nannochloropsis oculata microalgae and their mixture at 0, 1, 2, 3, 4, and 5% to three total mixed rations (TMRs) with different concentrate:forage ratios (40C:60F, 50C:50F, and 60C:40F) on in vitro gas production (GP), methane (CH) production, and nutrient degradability. Asymptotic GP, GP rate, CH concentration/g acid detergent fiber (ADF), dry matter (DM) degradability (DMD), short chain fatty acids (SCFAs), and ruminal bacteria population increased, but neutral detergent fiber (NDF) degradability (NDFD), ADF degradability (ADFD), and protozoa count decreased with increasing concentrate level in the TMR. Methane production/g DM and NDF was higher for 50C:50F TMR. Sunflower oil reduced asymptotic GP, lag time, CH production/g ADF, ammonia-N (NH-N), and SCFA. Compared to the control treatments, additives decreased GP rate, while sunflower oil/N. oculata mixture increased DMD and NDFD. All additives at 5% increased GP rate and lag time and decreased CH production/g DM, ADF, and NDF, ruminal NH-N, and protozoa count. All additives at 2% increased DMD, NDFD and ADFD, SCFA, and bacteria population. Supplementation of TMR, containing different concentrate:forage ratios, with sunflower oil, N. oculata, and sunflower oil/N. oculata mixture at different doses modified in vitro GP, CH production, and nutrient degradability.
BACKGROUND AND OBJECTIVEEosinophilic lung diseases are a diverse group of disorders characterized by pulmonary opacities associated with tissue or peripheral eosinophilia.DESIGN AND SETTINGA retrospective study conducted at two tertiary care hospitals from January 1999 to December 2009.METHODSAll cases with the diagnosis of pulmonary eosinophilia were reviewed over a period of 10 years. Data on demographic, clinical, and radiologic characteristics were collected.RESULTSThirty-five patients with a mean age of 33.9 (16.2) years, of which 20 (57.1%) were male and meeting the criteria of eosinophilic lung disease were identified. Cough and dyspnea were the most frequent symptoms at presentation in 29 (82.9%) and 27 (77.1%) patients, respectively. Reticulonodular and airspace patterns were the most common radiographic findings in 17 (48.6%) and 15 (42.9%) patients, respectively. Peripheral eosinophilia was present in 33 (94.3%) patients. Twenty-four patients (68.6%) were labeled as having idiopathic pulmonary infiltrate with eosinophilia. Complete remission was achieved in 13 (54.2%) of 24 patients, while 10 (41.7%) patients relapsed within a few months of discontinuation of therapy. Specific therapy for a specific disease was administered in 8 patients: 2 patients for pulmonary tuberculosis, 2 for Churg–Strauss syndrome, 1 for lymphoma, 1 for schistosomiasis, 1 for acute eosinophilic pneumonia, and 1 for Wegener granuloma; 3 patients were treated as allergic bronchopulmonary aspergillosis.CONCLUSIONSPulmonary eosinophilia remains rare but challenging, and it can have the same diverse clinical and radiographic presentations seen with other common pulmonary conditions. Clinicians should be alert to these syndromes and must think of them in any lung disease differential diagnoses.
he present study was conducted during the period from (September 2012 to April 2013) at the experimental farm station, belongs to Anim. Prod. Dept., Fac. of Agric., Al-Azhar Univ. Thirty pregnant Rahmani ewes with an avg. 33.7 kg LBW and 3 years old age were used to investigate the effect of vitamin E daily supplementation to pregnant ewes at late gestation and early lactation on the productive performance of treated ewes and their offsprings. Experimental animals were randomly assigned (28 days prepartum) to three nutritional groups; the 1 st one served as a control (nil vitamin E supplement). The 2nd and 3rd groups were daily and individually administrated 400 IU of α-tocopherol acetate (vitamin E), 28 days prepartum (T1) and for 28 days pre and 28 days postpartum (T2). Experimental animals were offered their daily requirements during pregnancy and early lactation according to NRC recommendations (1985). Results obtained showed that; supplementing pregnant ewes with vitamin E didn't lead to any positive influences on improving their daily milk yield or milk chemical composition, although there were significant differences among different experimental groups in daily milk yield. Ewes of T2 recorded higher (p<0.05) daily milk yield (417 g /h/d) in compare with (348 g /h/d) for the control ewes group and (292 g /h/d) for T1 ewes, respectively. Vitamin E supplementation to pregnant and lactating ewes didn't lead to significant differences in most of daily milk yield and chemical composition traits. Although, there were significant differences among different ewes groups in fat and SNF percentages in favor of the two supplemented ewes groups. Vitamin E supplementation to pregnant and lactating ewes didn't improve productive performance of both the two supplemented ewes groups and their progenies. Ewes of T1 group weaned more (p<0.05) kg of lambs, but without significant difference with those of the control group. Ewes of T2 weaned lower (p<0.05) kg lambs. Ewes of T2 and the control group one indicated more efficient feed utilization in compare with T1 group. Vitamin E supplementation didn't improve (p<0.05) lambs productive performance. Although, there were significant differences among different lambs groups in lambs avg. weaning weight, daily gain and lambs feed conversion ratio. Lambs born to T2 ewes consumed (p<0.05) higher milk intake (417 g/h/d), but lower feed conversion ratio (3.06 kg MI/kg gain), while lambs born to T1 ewes consumed lower milk (292 g/h/d), but with an improved FC ratio (1.75 kg MI /kg gain). Lambs born to the control ewes group consumed (348 g/h/d), but with more efficient FC ratio (2.20 kg milk intake / kg gain) in comparison with the corresponding lambs born to T2 ewes groups. Lambs born to T1 supplemented ewes recorded higher (p<0.05) avg. weaning weight (13.73 kg/h) and faster daily weight gain (179 g/h/d), without significant difference with lambs born to the control ewes group (165 g/h/d), while lambs born to T2 supplemented ewes indicated lower weaning weight (11.40 kg /h) and slower...
Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach distribution equilibrium about 40 min after salicylate administration. The equilibrium plasma fetal/maternal ratio for both salicylates averaged 0.4. Plasma concentrations of the two compounds in the mother and the fetus accorded with a two-compartment model having unusually large mean estimates (54 and 39 L) for the tissue distribution space of ASA and SA, respectively. Furthermore, the mean SA clearance in the ewe (358 mL X min-1) was much greater than that reported in man, while the mean ASA clearance (764 mL X min-1) was similar. Since ASA is an irreversible inhibitor of arachidonate cyclooxygenase, our findings reassert the need for caution in the use of the drug during pregnancy.
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