Eosinophilic pneumonia: experience at two tertiary care referral hospitals in Saudi Arabia

Abstract

BACKGROUND AND OBJECTIVEEosinophilic lung diseases are a diverse group of disorders characterized by pulmonary opacities associated with tissue or peripheral eosinophilia.DESIGN AND SETTINGA retrospective study conducted at two tertiary care hospitals from January 1999 to December 2009.METHODSAll cases with the diagnosis of pulmonary eosinophilia were reviewed over a period of 10 years. Data on demographic, clinical, and radiologic characteristics were collected.RESULTSThirty-five patients with a mean age of 33.9 (16.2) years, of which 20 (57.1%) were male and meeting the criteria of eosinophilic lung disease were identified. Cough and dyspnea were the most frequent symptoms at presentation in 29 (82.9%) and 27 (77.1%) patients, respectively. Reticulonodular and airspace patterns were the most common radiographic findings in 17 (48.6%) and 15 (42.9%) patients, respectively. Peripheral eosinophilia was present in 33 (94.3%) patients. Twenty-four patients (68.6%) were labeled as having idiopathic pulmonary infiltrate with eosinophilia. Complete remission was achieved in 13 (54.2%) of 24 patients, while 10 (41.7%) patients relapsed within a few months of discontinuation of therapy. Specific therapy for a specific disease was administered in 8 patients: 2 patients for pulmonary tuberculosis, 2 for Churg–Strauss syndrome, 1 for lymphoma, 1 for schistosomiasis, 1 for acute eosinophilic pneumonia, and 1 for Wegener granuloma; 3 patients were treated as allergic bronchopulmonary aspergillosis.CONCLUSIONSPulmonary eosinophilia remains rare but challenging, and it can have the same diverse clinical and radiographic presentations seen with other common pulmonary conditions. Clinicians should be alert to these syndromes and must think of them in any lung disease differential diagnoses.

Mepolizumab and dupilumab as a replacement to systemic glucocorticoids for the treatment of Chronic Eosinophilic Pneumonia and Allergic Bronchopulmonary Aspergillosis - Case series, Almoosa specialist hospital

“…Asthma is less commonly associated with peripheral eosinophilia, however, marked levels of eosinophilia should warrant further investigations [ 3 ]. Only three types of pulmonary eosinophilia are associated with bronchial asthma these are CEP, ABPA, and Eosinophilic granulomatosis with polyangiitis (EGPA).…”

Health-Related Quality of Life of Asthmatic Patients in Al-Baha City, Saudi Arabia

“…One of the most prevalent chronic illnesses in Saudi Arabia is asthma, and local reports indicate that the condition is becoming more prevalent [6][7][8][9]. A previous Saudi study evaluated the impact of asthma on the quality of life of persistent asthmatic patients and its relationship to asthma control and pulmonary function.…”

The effect of salbutamol sulphate inhalation (an anti‐asthmatic medication) on the surfaces of orthodontic Archwires

“…9 Orthodontic treatment is becoming a popular therapy nowadays, and as more individuals seek treatment, the chances of those having asthma could also increase. 1,10 Since salbutamol sulphate is usually used in an inhalation form and is considered an acidic drug with a pH of 3.5-5, 11 it may affect dental materials in vivo, including orthodontic appliances such as archwires. This is of clinical importance in orthodontics as smooth archwire surfaces reduce unwanted friction, especially during sliding mechanics.…”