Introduction: Prolonged rupture of membrane (PROM) is an important risk factor for early onset neonatal sepsis (EONS), which is associated with increased neonatal morbidity and mortality. This study is mainly done to know the outcome of neonates born to mothers with history of PROM. Methods: This study was conducted from January 2015 to December 2015 for a period of 12 months, in GSL medical college and hospital, Rajahmundry. Selection of cases-All the neonates born to mothers with history of prolonged rupture of membranes >18hrs were included in our study. Required investigations were done and followed during their hospital stay. Results: Out of 200 neonates born to mothers with PROM, 60 had clinical sepsis, 29 had confirmed sepsis. Out of 29 confirmed cases of sepsis, positive blood culture was seen in 22 cases. The incidence of EONS in present study was found to be 14.5%. In present study neonatal sepsis had a higher rate of incidence in preterm neonates (61.5%) than in term neonates (38.5%). The incidence of neonatal sepsis was found to be lower in neonates born to mothers who took prenatal antibiotic treatment (9.25%) as compared to neonates born to mothers who did not receive prenatal antibiotic treatment (20.65%). Respiratory distress was the commonest presenting clinical sign (33 cases). Out of all the five Sepsis screen parameters C-Reactive Protein has the highest sensitivity (90.90%). Conclusion: Preventive measures should focus on recognition of these high-risk infants with prompt laboratory screening for sepsis and early institution of empirical antibiotic based on local data
Background: Infants who are clinically jaundiced in the first few days are more likely to develop hyperbilirubinemia. The present study was made attempt to evaluate the predictive value of serum bilirubin level on day one postnatal age for identifying term neonates at risk for subsequent hyperbilirubinemia.Method: The present hospital based prospective study involving neonate’s ≥37 weeks of gestational age included 200 healthy term newborn babies (≥37weeks GA) born at GSL medical college and hospital at Rajahmundry during study period. The purpose of this study was explained to the parents/ guardian and written consent was taken prior to the study. Data collected was kept securely. Permission was obtained from the Ethical Committee of GSL medical College before starting the study.Result: Newborns who developed significant hyperbilirubinemia male: female ratio was 1.07:1. 9(33%) newborns with significant hyperbilirubinemia had jaundice in previous siblings. In the present study, the value of 4.9 mg/dl was determined to have the best combination of sensitivity and specificity to predict neonates at risk of hyper birubinemia subsequently. At this value of 4.9 mg/dl there is high sensitivity and a very high negative predictive value, although a low positive predictive value for predicting neonates likely to develop significant hyperbilirubinemia.Conclusion: Early screening and appropriate management of hyperbilirubinemia is needed for prevention of complications in the newborn. This decreases the significant burden of untreated severe neonatal jaundice, causing potential neurological sequelae. Prediction of neonatal hyperbilirubinemia has widespread implication especially in our country where there are limited resources.
Background: Iron stores of neonates born to anaemic mothers are low, iron content in breast milk in anaemic women is low and because of these factors substantial proportion of infants become anaemic by six months. Thus maternal iron deficiency and anaemia makes the offspring vulnerable for developing iron deficiency anaemia right from infancy. The current study was made attempt to evaluate and establish the relationship between maternal haemoglobin and early neonatal outcome in term babies.Method: The present cross-sectional observational study conducted in term neonates and their mothers in first stage of labour in the Department of Paediatric and Department of Obstetrics & Gynaecology, GSL Medical College and general hospital, Rajamahendravaram, from 2015 to 2017. Relevant history of mother was recorded and blood sample from the mother was collected in first stage of labour for haemoglobin estimation.Result: The mean haemoglobin in anaemic mothers was found to be 9.48±0.413 gm/dl and that in non-anaemic mothers was 11.67±0.515gm/dl. Anaemia among mothers has significant effect on birth weight of the newborn babies, on crown heel length of the newborn babies (P<0.05) and on head circumference of Newborn babies (P< 0.05). It was found that anaemia among mothers has no significant effect on APGAR score at 5 mins and on hospital stay.Conclusion: Anaemic mothers had newborn with low mean birth weight, low mean head circumference and low crown heel length compared to the those of non anaemic mothers.
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