This study demonstrates the efficacy of a three-step (64)Cu pretargeting procedure for PET imaging of apoptosis. Our data also confirm the usefulness of small animal PET to evaluate cancer treatment protocols.

We present a simple fabrication technique for lateral nanowire wrap-gate devices with high capacitive coupling and field-effect mobility. Our process uses e-beam lithography with a single resist-spinning step, and does not require chemical etching. We measure, in the temperature range 1.5-250 K, a subthreshold slope of 5-54 mV/decade and mobility of 2800-2500 cm 2 /V s -significantly larger than previously reported lateral wrap-gate devices. At depletion, the barrier height due to the gated region is proportional to applied wrapgate voltage.

This report presents the design and testing of an external target system for clinical‐scale production of 211At on the Scanditronix MC‐50 cyclotron at the University of Washington Medical Center. While other 211At production sites have typically employed an internal target, an external target setup was deemed necessary at our facility since the cyclotron's main application is for cancer patient treatment via fast neutron therapy. The challenge was that previous external 211At targets demonstrated reduced yields when compared to internal target systems. The target developed in this study has been used in more than 100 irradiations. From those irradiations 211At saturated yields of 181 ± 16 MBq/μA and 241 ± 17 MBq/μA at 28.0 and 29.0 MeV, respectively, were obtained. Importantly, consistent yields were observed over the 25–60 μA range of irradiation currents evaluated. With a recent production in excess of 4 GBq 211At for a 29.0 MeV, 58 μA, 4‐hour irradiation, this external target system has demonstrated its potential for producing clinically relevant quantities of 211At.

No abstract

No abstract