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Comparative study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging

“…64 Cu was prepared on an EBCO TR-19 cyclotron (EBCO Technologies, Vancouver, Canada) by the 64 Ni(p, n) 64 Cu nuclear reaction using an enriched 64 Ni target electroplated on a rhodium disk [33]. [ 64 Cu]CuCl 2 was recovered from the target following the procedure of McCarthy et al [34] and converted to [ 64 Cu]copper[II] acetate by dissolving the [ 64 Cu]CuCl 2 in ammonium acetate (0.1 M; pH 5.5).…”

Molecular imaging with copper-64

“…For relatively thin 64 Ni targets (0.094-0.120 g cm À2 ), yields using 15.5 MeV protons at 53-139 lA h were comparable to predicted values, while the yield of the thicker target (0.28 g cm À2 ) was only half the predicted yield. Other researchers have obtained similar results with 15 MeV protons on enriched 64 Ni, where yields varied from 2700 to 4200 lCi/lA h for targets ranging from 0.2 to 0.5 g cm À2 [72]. Using an ultra small medical cyclotron Obata et al [73] recently reported production of 64 Cu with 12 MeV protons on 64 Ni.…”

“…Production of 64 Cu is readily achieved using either a cyclotron or a reactor [50,51,55,[60][61][62][63][64][65][66][67][68][69][70][71][72][73]. In the 1980Õs and 1990Õs much of the research explored the production off 64 Cu using cyclotrons, as higher specific activities were achievable by these routes (see Table 3).…”

Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity

“…Labeling of a NOTA-ML was performed as reported previously [12] using 64 Cu prepared via the 64 Ni(p,n) 64 Cu reaction using an enriched 64 Ni target electroplated on a rhodium disk [14]. The peptide was labeled with 64 Cu under previously optimized conditions [15] as follows: a peptide (5  μ g) was incubated with [ 64 Cu]Cu-(OAc) 2 (300−370 MBq; 8−10 mCi) in ammonium acetate buffer (0.1 M, pH 5.5) and heated at 95°C for 10 min.…”