Background-Euphorbia prostrata possesses many actions one of which is wound healing. Skin wound healing is a significant health care problem which clinician faces still. Hence this study was planned to evaluate effect of euphorbia prostrata on skin wound healing. Material and methods-This study was conducted among randomly selected wistar rats (n=6 per group). Group A and Group B had Cream and 1% euphorbia prostrate cream applied topically on the excisional wound respectively. Wound healing and epithelisation was assessed on Days 4,8,12,16,20. Results: Group A showed an average wound size of 348±13.0 on day 4, 278±10.5 on day 8, 119±9.8 on day 12, 86±9.2 on day 16 and 100% wound healing was observed day 20 onwards. Group B showed an average wound size of 296±11.0 on day 4, 147±9.5 on day 8 and complete wound healing was observed day 12 onwards in the test group. Conclusion: Euphorbia prostrata holds promise as effective drug therapy for wound healing.