Effect of Euphorbia Prostrata on the Wound Healing in Excisional Wound Model in Rats

Abstract

Background-Euphorbia prostrata possesses many actions one of which is wound healing. Skin wound healing is a significant health care problem which clinician faces still. Hence this study was planned to evaluate effect of euphorbia prostrata on skin wound healing. Material and methods-This study was conducted among randomly selected wistar rats (n=6 per group). Group A and Group B had Cream and 1% euphorbia prostrate cream applied topically on the excisional wound respectively. Wound healing and epithelisation was assessed on Days 4,8,12,16,20. Results: Group A showed an average wound size of 348±13.0 on day 4, 278±10.5 on day 8, 119±9.8 on day 12, 86±9.2 on day 16 and 100% wound healing was observed day 20 onwards. Group B showed an average wound size of 296±11.0 on day 4, 147±9.5 on day 8 and complete wound healing was observed day 12 onwards in the test group. Conclusion: Euphorbia prostrata holds promise as effective drug therapy for wound healing.

Memory enhancing potential of Euphorbia prostrata through antioxidant, anti-inflammatory, and anti acetylcholinesterase effect against Scopolamine -induced Alzheimer’s disease in Wistar albino rats

“…The different parts of this herb have been reported to have numerous pharmaceutically active constituents including phytosterols, flavonoids, polyphenols, and phenolic compounds [11,12]. Contemporary research reveals that phytoconstituents of the plant endorse the numerous conventional therapeutic uses of E. prostrata against warts, gonorrhea, skin infections, migraines, parasitic infection, and viral diseases along with its previously reported therapeutic actions such as anthelmintic activity [13], anticandidal activity [14], analgesic [15], wound healing [16], antioxidant [12], insecticidal activity, antihyperglycemic activity, hypolipidemic effect [17], and antitumor activity [18]. Despite such a diverse pharmacological arena, the plausible therapeutic action in neurodegenerative disorders by endorsing traditional therapies including phytoconstituents and homeopathy, the underlying molecular mechanism is still a challenge now a days [19].…”

Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection

“…These plants identified were Solanum nigrum, Euphorbia prostrata, Acalypha indica, Lantana camara and Ricinus communis. A literature search to identify the phytoconstituents of these plants revealed that they contain flavonoids, flavonoid glycosides (Huang et al, 2010;Patil and Limaye, 2017), triterpenoids (Ghisalberti, 2000), steroidal glycoalkaloids (Gu et al, 2018) and other compounds of different classes (Herbert et al, 1991;Nahrstedt et al, 1982;Tai et al, 2018). Furthermore, it has been reported that flavonoids can bind to the SARS-CoV-2 S protein, a viral surface glycoprotein required for initial attachment and internalization within host cells (Rane et al, 2020).…”