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2000 polyphenyl derivatives polyphenyl derivatives Q 0700 21 -098 Directed ortho Metalation and Suzuki-Miyaura Cross-Coupling Connections: Regiospecific Synthesis of all Isomeric Chlorodihydroxybiphenyls for Microbial Degradation Studies of PCBs. -The synthesis of six isomeric chlorodihydroxybiphenyls, e.g. (IVb), (IX), and (XIV), is carried out by combining the directed ortho metalation with the Pd-catalyzed Suzuki-Miyaura cross-coupling reaction. The key conceptual features include new strategies of oxygen-directed metalation group use in walk-around-the-ring functionalization ((IX), (XIV)). -(NERDINGER, S.; KENDALL, C.; MARCHHART, R.; RIEBEL, P.; JOHNSON, M. R.; YIN, C.-F.; ELTIS, L. D.; SNIECKUS, V.; Chem. Commun. (Cambridge) (1999) 22, 2259-2260; Dep. Chem., Queen's Univ., Kingston, Ont. K7L 3N6, Can.; EN)