Background Platinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action. Results A series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1 mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23 µg/ml in MCF7, 47.55 µg/ml in HeLa, 48.96 µg/ml in HCT116 and 76.83 µg/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51 µg/ml in MCF7, 58.6 µg/ml in HeLa, 62.58 µg/ml in HCT116 and 154.2 µg/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway. Conclusion Our results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.
Palliative care is given much importance in the curriculum of medical and health sciences. Before planning a new design and curriculum development, it is mandatory to test the knowledge and awareness of Occupational therapy students on palliative care. Thus it will help the expert’s panel to enhance the syllabus designing methods appropriate to the student’s knowledge. Without paying much attention to enhance knowledge on palliative care among students might lead to failure in providing quality care. To evaluate the knowledge in palliative care among undergraduate occupational therapy students. The study population included BOT 1ST Year and BOT Final year students and CRI from SRM College OF Occupational therapy, Kattankulathur. After obtaining informed consent signed from the participants, they have been instructed to fill in the questionnaire. The questionnaire has demographic data and 35 questions under nine groups, for which the students were instructed to answer (Yes, No, Don’t know). A detailed instruction was there in the questionnaire to avoid leaving any questions blank. It was found that occupational therapy students were aware of palliative care. Knowledge in palliative care was not precise among occupational therapy students related to healthcare. Hence there is an emerging need to include palliate care in the curriculum for the development of knowledge in palliative care.
Breastfeeding is useful for both the mother and child, and it is known as an effective method to reduce childhood morbidity and mortality. This study intended to reveal the infant breastfeeding experience of women in Cuddalore district, Tamilnadu, India, as well as to explore the problems from breastfeeding among them. A Qualitative study design was adopted, and 20 breastfeeding women in the Pediatric ward of Rajah Muthiah Medical College & Hospital (RMMCH), Cuddalore district, Tamilnadu, India were selected using purposive sampling. Data on demographic variables, physical and social dimensions of breastfeeding mothers were collected using a semi-structured interview schedule and analyzed using descriptive statistics. Results showed that 95% of mothers had no previous education about breastfeeding. All the selected mothers had experienced latching difficulty and burping problem and also received adequate family support from their mother and relatives. Other breastfeeding difficulties such as lack of milk secretion, pain over the breast, breast engorgement, headache, fatigue and disturbed sleep were also identified among mothers. All 20 mothers did not participate in any social gathering about breastfeeding. This study revealed the difficulties faced by mothers in physical and social dimensions and recommended the need for social initiatives to encourage breastfeeding.
The study aims to compare the scores of dominance and non-dominance in developing children that are important in clinical practice. The capacity to perform complex muscle and nerve acts that produce development; fine engine aptitudes are little developments; net engine abilities are enormous developments. An observational quantitative study was conducted to establish the new developmental norms for children on the Box and Block Test. This study included 400 volunteers’ 221(55.25%) males and 179(44.75%) females with the age of 6 to10 years. The signed parental consent before participation was obtained in this study. Out of 400 total populations, the male’s right dominance is 20(93.6%) is a difference from left dominance 14(6.4%). The female right dominance is 171(95.5%) is more than that of male dominance and used to compare the left dominance 8(4.5%). The Block and Test Box are easy, simple, and suitable for children. This test aids the therapists to evaluate the efficacy of the interventions tailored to improve manual dexterity. These kids may profit essentially from early mediation focusing on the improvement of handwork.
The commonness of Internet Addiction (IA) among well-being science undergrads has not been accounted for utilizing a huge example. To explain the genuine status of addictive Internet use among well-being science undergrads, this examination meant to assess the commonness and the hazard variables of IA and in danger IA among well-being science understudies in south India. This cross-sectional investigation studied all well-being science undergrad workforces in Kattankulathur Prefecture, a country zone in India. Qualified members included 1165 understudies' students (533 men and 632 women). Members finished a poll on their exercises and factors identified with Internet use. The pervasiveness of IA and in danger IA was 24.7% and 26.8%, individually. Besides, game playing was demonstrated to be Internet action most firmly connected with in danger IA. This examination demonstrated that around 27% of well-being science undergrads in an urban/provincial region in India are in danger of building up a dependence on the internet and that utilizing the internet for game playing is identified within danger IA. Our outcomes propose that well-being science understudies ought to be told to utilize the internet appropriately and rouse to a valuable path for study and information purposes.
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