The objective of this study was to evaluate sexual function in women with rheumatoid arthritis (RA) using an auto-questionnaire Female Sexual Function Index (FSFI) and study its correlation with disease activity. Sixty patients with RA and 40 healthy controls were included in this exploratory study. Sociodemographic, clinical, and laboratory characteristics were assessed. The disease activity was assessed by auto-questionnaires Routine Assessment of Patient Index Data 3 (RAPID3) and Rheumatoid Arthritis Disease Activity Index 5 (RADAI5) judged by 28 DAS ESR. Sexual function was assessed by an auto-questionnaire specific for female sexuality: FSFI during the last 4 weeks. The definition of sexual dysfunction was considered by FSFI score less than or equal to 26.5. The mean age of RA patients and controls was 45.95 ± 9.3 and 45.01 ± 9.2, respectively. According to FSFI, the percentage of FSD in women with RA was significantly higher than that in the control group. All dimensions of sexuality were affected (desire, arousal, lubrication, orgasm, and satisfaction) except pain. The multivariate linear regression analysis indicated that the swollen joints and the RADAI5 were the independent variables of disease activity associated with sexual dysfunction in women with RA. This study suggests that sexual dysfunction among women suffering from rheumatoid arthritis is found when a targeted questionnaire is used to identify it and that the increased disease activity has a negative effect of sexual function.
IntroductionTo assess the prevalence of sexual dysfunction in married women with rheumatoid arthritis (RA) and compare it with a control group and to determine its association with clinical and disease activity factors.MethodsWe conducted a cross-sectional study including sixty married women with a confirmed diagnosis of Rheumatoid Arthritis according to the American College of Rheumatology (ACR)/ European League against Rheumatism (EULAR) 2010 Criteria, aged 18 or over and having sexual activity. Our controls were healthy volunteers women matched for age. Clinical and sociodemographic characteristics were collected. Sexual function was assessed by a self-reported questionnaire the index of female sexual function (FSFI). Sociodemographic and disease activity profiles were compared between those who had and did not have sexual dysfunction.ResultsThe prevalence of female sexual dysfunction in women with rheumatoid arthritis attending El Ayachi hospital was 71.9%, it was 54% in controls. There was a significant difference in the total FSFI score between patients 18.29±9.09 and controls 23.05±7.91 (p=0.016). We found a statistically significant difference between the two groups in almost all dimensions of sexual function (desire, arousal, orgasm, satisfaction), except for pain and lubrication. In multivariate analysis, pain assessed by visual analogue scale (VAS) and depression assessed by hospital anxiety and depression score (HAD) were the independent determinants of sexual dysfunction.ConclusionOur study suggests that sexual dysfunction is more common among patients with RA compared to controls. These dysfunctions were related to desire, arousal, orgasm and satisfaction. Pain and depression appear to be the most important predictors of sexual dysfunction.
BackgroundMetabolic syndrome, a cluster of classical cardiovascular risk factors, including hypertension, obesity, glucose intolerance, and dyslipidemia is highly prevalent in patients with rheumatoid arthritis (RA). The aim of the study was to assess the frequency of metabolic syndrome (MS) in RA patients, and to evaluate the relationships between metabolic syndrome and RA.MethodsThe study was conducted on 120 RA patients according to the 1987 revised American College of Rheumatology classification criteria, and 100 age and sex matched apparently healthy controls. The frequency of metabolic syndrome was assessed using six Metabolic Syndrome definitions (Joint Consensus 2009, National Cholesterol Education Programme 2004 and 2001, International Diabetes Federation, World Health Organisation and European Group for Study of Insulin Resistance). Logistic regression was used to identify independent predictors of metabolic Syndrome.ResultsThe frequency of metabolic syndrome varied from 18 to 48.6% in RA according to the definition used and was significantly higher than controls (for all definitions p<0.05). In multivariate analysis, higher ESR was independently associated with the presence of Met S (OR =1.36; CI: 1.18–2.12; p = 0.03). Glucocorticoid use, but not other disease modifying anti-rheumatic drugs (DMARDs), values remained significant independent predictors of the presence of metabolic syndrome in RA patients (OR = 1.45; CI: 1.12–2.14; p = 0.04).ConclusionsIn summary, the frequency of metabolic syndrome in RA varies according to the definition used and was significantly higher compared to controls (for all definitions p<0.05). Higher systemic inflammatory marker, and glucocorticoids use were independent predictors associated with the presence of metabolic syndrome in patients with RA. These findings suggest that physicians should screen for metabolic syndrome in patients with RA to control its components and therefore reduce the risk of cardiovascular disease in these patients.
Objectives To evaluate the correlation between the questionnaire of impact of Rheumatoid Arthritis (RAID: Rheumatoid Arthritis Impact Disease) and questionnaires for assessing disease activity judged by patient (RAPID-3: Routine Assessment of Patient Index Data 3, and RADAI-5: Rheumatoid Arthritis Disease Activity Index5) and composite indicesfor assessment of disease activity (DAS28-ESR: activity score of 28 joint disease activity index CDAI and clinical disease) in daily practice. Methods A cross sectional study in patients with rheumatoid arthritis according to the2010 ACR/EULAR criteria was conducted. All patients completed the following questionnaires RAID, RADAI 5and RAPID-3. The DAS28-ESR and the CDAI were measured simultaneously. The reliabilitywas calculated by Cronbach's alpha and factorial analysis was performed. The correlation coefficient “tau” of Kendall was used to analyze the correlation between different instruments. Results Thirty patients with RA were included. The mean age was51±11 years with a female predominance (80%). Time to complete the questionnaires was 30 seconds. The median for RADAI-5 was 3.9 (1.7 to 4.9), 4.05 for the RAPID-3 (1.91 to 5.13), 4.47 for the RAID (2.31 to 5.78).Cronbach's alpha was excellent for RADAI-5 (α=0.99), RAPID-3 (α=0.99) and RAID (α=0.99). The “tau” concordance was 0.78, 0.76, 0.74, and 0.82 between RAID and respectively RAPID3, RADAI5, DAS28ESR, CDAI. (p<0.001 was highly significant for all variables). Conclusions The reliability of the questionnaire RAID is as good ascomposite indices.The questionnaires showed a good agreement with each other and indices. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5236
Objectives Evaluate the association between corticosteroid therapy, body composition and bone mineral density in patients with juvenile idiopathic arthritis. Methods Our study was a cross-sectional study including Moroccan patients with juvenile idiopathic arthritis according to the International League of association of Rheumatology (ILAR) criteria, seen in rheumatology consultation or hospital. Sociodemographic and clinical data of the patients were collected. Bone mineral density of patients (BMD g/cm2) was measured by DXA X-ray Lunar Prodigy scanner. It was measured in two sites: the lumbar spine (L1, L4) and the whole body. Lean and fat mass were measured by the same device at the whole body and expressed in grams. Results 33 patients were included, the mean of their age was 10±4.35 years old, with a male predominance (54.5%), the median of disease evolution was 2 (1 - 4.5) years. Twenty for percent had a systemic JIA, 27% had an oligoarticular JIA and 48% had a polyarticular JIA. nineteen (57.6%) of our patients were receiving corticosteroid therapy, the median of daily intake dose was 10mg (0-15), the median of treatment duration was 3 years (1-6) and the median of cumulative dose was 10950mg (5475 -21 900). The median of BMD in the whole body, lumbar spine, lean mass and fat mass were respectively 0.720 g/cm2 (0700-0900) 0.620 g/cm2 (0530-0900), 20.49g (15.96-33.45), 4.97g (3.63-15.09). There was no significant correlation between the daily dose of corticosteroids and lean body mass (p=0.23), fat mass (p=0.21), BMD of the lumbar spine, p=0.82 or BMD of whole body p=0.86. We didn't find a significant correlation between the cumulative dose of corticosteroids and lean body mass (p=0.079), fat mass (p=0.05), lumbar spine BMD (p=0.27) and the hole body BMD (p=0.36). Conclusions This study suggests that taking steroids does not affect the BMD or body composition in children with JIA. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5806
Objectives To determine the factors influencing bone mineral content in patients with juvenile idiopathic arthritis. Methods A cross sectional studyin patientswith juvenile idiopathic arthritis (JIA) according to the International League of Association of Rheumatology criteria was conducted. Sociodemographic parameters and clinical data related to the disease were collected. Bone mineral content was measured by dual energy X-ray absorptiometry on Lunar Prodigy machine at the full body. Disease activity of the JIA was assessed by the number of painful joints (PJ), number of swollen joints (SJ), the visual analogic scale (VAS) pain assessed by patient (VASp) and physician (VASd), and biological parameters (ESR,CRP). Biochemical markers of bone turnover were represented by serum calcium, phosphorus and alkaline phosphatase. Normal serum calcium in children <3 years is 88-110 mg/l and for children>3 years: 90-105 mg/l. For phosphate: 40-60 mg/l. For alkaline phosphatase: 90-450 IU/l. The daily food intake was assessed by a questionnaire for 7 consecutive days. Two nutritionists analyzed the diet to identify its macronutrient and oligonutriments content. Food intake was analyzed by Bilnut Version 2.01 software 1991. Results Thirty-three patients with JIA were included. The mean age was10±4.35 years with amale predominance 54.5%. Twenty-four percent had a systemic form, 27% an oligoarticular and 48% a polyarticular form. The median disease duration was 2 years (1 - 4.5). The median duration of taking corticosteroids was 3 years (1-6). The median rate of vitamin D was 20ng/ml (13.85-31.5), for serum calcium 95 mg/l (93-97). The mean rate of phosphorus was 45mg/l ±7.36. The mean rate of alkaline phosphatase was 161UI/l ±52.The median of CMO, PJ, SJ, VASp, VAS d, ESR and CRP were respectively 1044.97g (630-1808), 3 (1-9), 1 (0 - 3), 20 (10-50) 35 (25-50.5) 20 (10.5-40). There was no correlation between bone mineral content and JIA disease activity parameters: PJ (r =0.06, p=0.77), SJ (r =0.25, p=0.23), VASp (r =0.16, p=0.46), VASd (r =0.02, p=0.91), ESR (r =0.13, p=0.54), CRP (r =0.10, p=0.64).There was no correlation between the bone mineral content and the cumulative duration and corticosteroid dose taken with respectively (r =0.15, p=0.61) (r =0.28, p=0.33).There was a positive correlation between the rate of phosphorus and bone mineral content as well as alkaline phosphatase with respectively (r =0.47, p=0.02) (r =0.41, p=0.04) while the CMO is not correlated with the rate of vitamin D (r =0.14, p=0.5) or the serum calcium levels (r =0.11, p=0.59). Conclusions This study suggests that bone mineral content was correlated with markers of bone turnover such as alkaline phosphatase and serum phosphate. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5295
Objectives To evaluate the prevalence of anemia in patients with rheumatoid arthritis and analyze its relationship with parameters of disease activity from the QUEST-RA data Moroccan. Methods Moroccan QUEST-RA (Quantitative Standard Monitoring Patients with Rheumatoid Arthritis), inspired from Finnish QUEST-RA. Moroccan QUEST-RAis a national multicentric cross-sectional study of patients with rheumatoid arthritis (according to the 1987 ACR criteria) enrolled in public and private sectors, over a period from January 2008 to December 2010. Pre-established questionnaire containing sociodemographic, clinical and paraclinical characteristics was completed by all patients. Patients were divided into two groups: a group with anemia (hemoglobin <13 g / dl in men, <12g/dl in women) and a group without anemia (hemoglobin ≥ 13g/dl in women and ≥ 12g/dl humans) according to the criteria of the World Health Organization. The parameters of disease activity were assessed by EVA patient, EVA doctor, erythrocyte sedimentation rate (ESR), C- Reactive protein (CRP) and DAS-28 ESR. Results 1129 patients with RA were eligible. The mean age of patients was 48.8 ± 12.7 years with female predominance (87.3%). The median disease duration was 6 years (3-12), the mean DAS28 ESR was 4.94 ± 1.68, the median HAQ was 1 (0.37-1.62). The prevalence of anemia was 28.8%. In univariate analysis, there was a significant association between the presence of anemia, ESR, CRP, HAQ with respectively [(OR = 1.20, 95% CI (1.01-1.40)) (OR = 1.02, 95% CI (1.01 to 1.04)) (OR = 2.07, 95% CI (1.74 to 3.47)) (for all p <0.05)]. Moreover, there was no association between anemia and the presence of comorbidities (ulcer; IDM, vascular pathology ….). In multivariate analysis, only persist an association between anemia, ESR (OR = 1.02, 95% CI (1.01 to 1.06)) and HAQ (OR = 1.04, 95% CI (1.01 to 1.60)) for all p <0.05. Conclusions This study suggests that the prevalence of anemia was common and appeared to be independently associated with disease activity. Further studies are needed. Acknowledgements Dr Samir Ahid: Laboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy. Rabat. Morocco. Disclosure of Interest None Declared
Objectives Translate, adapt and validate in patients with rheumatoid arthritis a self-assessment questionnaire of female sexual function: (FFSI) The Female Sexual Function Index Methods It is a cross-sectional study including 31 patients with rheumatoid arthritis according to the 1987 ACR criteria in period of sexual activity. The FSFI is a self-administered questionnaire that assesses sexual function during the past 4 weeks, it is composed of six domains respectively assessing desire, arousal, lubrication, orgasm, satisfaction and pain. The FSFI total score varies between 1.2 and 36, a score ≤ 26 defines sexual dysfunction. Translation and adaptation of the FSFI in classical Arabic was performed according to international recommendations for the translation of questionnaires (translation, back translation, committee of expert). The acceptability, reliability, internal and external construct validity of the arabic version were evaluated. External construct validity was assessed by analyzing the correlation between this instrument and the quality of life of patients assessed by the SF-36 (short form health survey), anxiety and depression assessed by the HAD (hospital anxiety and depression scale) Results The average age of our patients was 45 ± 9.10 with a median disease progression of 60 months (24-144). The mean DAS28 was 4.59 ± 1.81 and the median HAQ was 0. 75 (0.25 to 1.22). Reliability was excellent, the intraclass correlation coefficient of FSFI: ICC was 0.995 (95% CI :0.98-0 .99). Reproducibility measured by Cronbach’s alpha coefficient was 0.997. we did not find significant correlation between the FSFI total score and the different areas of SF36 (physical activity r = 0.23, p = 0.22) (limitation due to the physical state r = 0, 30, p = 0.22) (limitation due to mental health r = 0.30, p = 0.1) (vitality r = 0.27, p = 0.14) (mental health r=0.06, p = 0.14); (pain r = 0.25, p = 0.17), perceived health r = 0.31, p = 0.09) except for the field (relationship with other living r = 0.740, p <0.001). In addition, we did not notice any correlation with areas of HAD (HAD anxiety r = -0.6, p = 0.75) (HAD depression r = -0.27, p = 0.27). In the other hand a good correlation was found between the FSFI score and overall sexual satisfaction of patients as measured by a visual analogue scale from 0 to 10 cm (Pearson r = 0.50, p = 0.01) Conclusions The psychometric properties of the FSFI are good. This tool translated into Arabic and may be useful in the evaluation of female sexual function of both Moroccan and Arab women. Disclosure of Interest None Declared
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.