IntroductionTo assess the prevalence of sexual dysfunction in married women with rheumatoid arthritis (RA) and compare it with a control group and to determine its association with clinical and disease activity factors.MethodsWe conducted a cross-sectional study including sixty married women with a confirmed diagnosis of Rheumatoid Arthritis according to the American College of Rheumatology (ACR)/ European League against Rheumatism (EULAR) 2010 Criteria, aged 18 or over and having sexual activity. Our controls were healthy volunteers women matched for age. Clinical and sociodemographic characteristics were collected. Sexual function was assessed by a self-reported questionnaire the index of female sexual function (FSFI). Sociodemographic and disease activity profiles were compared between those who had and did not have sexual dysfunction.ResultsThe prevalence of female sexual dysfunction in women with rheumatoid arthritis attending El Ayachi hospital was 71.9%, it was 54% in controls. There was a significant difference in the total FSFI score between patients 18.29±9.09 and controls 23.05±7.91 (p=0.016). We found a statistically significant difference between the two groups in almost all dimensions of sexual function (desire, arousal, orgasm, satisfaction), except for pain and lubrication. In multivariate analysis, pain assessed by visual analogue scale (VAS) and depression assessed by hospital anxiety and depression score (HAD) were the independent determinants of sexual dysfunction.ConclusionOur study suggests that sexual dysfunction is more common among patients with RA compared to controls. These dysfunctions were related to desire, arousal, orgasm and satisfaction. Pain and depression appear to be the most important predictors of sexual dysfunction.

Objectives To determine the factors influencing the lean body mass in patients with juvenile idiopathic arthritis. Methods A cross sectional study in patients with juvenile idiopathic arthritis (JIA) according to the International League of Association of Rheumatology criteria was conducted. Sociodemographic parameters and clinical data related to the disease were collected. Lean body mass was measured by dual energy X-ray absorptiometry on Lunar Prodigy machine at the full body. Disease activity of the JIA was assessed by the number of painful joints (PJ), number of swollen joints (SJ), thevisual analogic scale (VAS) painassessed by patient (VASp) and physician (VASd), and biological parameters (ESR,CRP). The daily food intake was assessed by a questionnaire for 7 consecutive days. Two nutritionists analyzed the diet to identify its macronutrient and oligonutriments content. Food intake was analyzed by Bilnut Version 2.01 software 1991, which was validated. Results Thirty-three patients with JIA were included. The mean age was 10±4.35 years with a male predominance (54.5%). Twenty-four percent had a systemic form, 27% an oligoarticular and 48% a polyarticular form. The median disease duration was 2 years (1-4.5). The median duration of taking corticosteroids was 3 years (1-6).The median of lean mass, PJ, SJ, VASp, VAS d, ESR and CRP were respectively 20.5g (15.96-33.45), 3 (1-9), 1 (0-3), 20 (10-50) 35 (25-50.5) 20 (10.5-40).The median content of the feed proteins, lipids and carbohydrates was respectively1.7g (0-4.75), 0.8 g (0-11.65), and 11.1g (0-32.8).There was no correlation between lean mass and JIA disease activity parameters: PJ (r=0.06, p=0.7), SJ (r=0.25, p=0.23), VASp (r=0.16, p=0.46), VASd (r=0.02, p=0.9), ESR (r=0.13, p=0.54), CRP (r=0.10, p=0.64).There was no correlation between lean body mass and the cumulative duration and taking of corticosteroids with respectively (r =0.15, p=0.61) dose (r=0.28, p=0.33).There was no correlation between lean mass and content of feed on protein (r=0.17, p=0.41), fat (r=0.14, p=0.32), or carbohydrate (r=0.32, p=0.12). Conclusions This study suggests that there was no correlation between lean body mass, disease activity parameters, and taking corticosteroids in children with JIA. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5267

Objectives To evaluate the correlation between the questionnaire of impact of Rheumatoid Arthritis (RAID: Rheumatoid Arthritis Impact Disease) and questionnaires for assessing disease activity judged by patient (RAPID-3: Routine Assessment of Patient Index Data 3, and RADAI-5: Rheumatoid Arthritis Disease Activity Index5) and composite indicesfor assessment of disease activity (DAS28-ESR: activity score of 28 joint disease activity index CDAI and clinical disease) in daily practice. Methods A cross sectional study in patients with rheumatoid arthritis according to the2010 ACR/EULAR criteria was conducted. All patients completed the following questionnaires RAID, RADAI 5and RAPID-3. The DAS28-ESR and the CDAI were measured simultaneously. The reliabilitywas calculated by Cronbach's alpha and factorial analysis was performed. The correlation coefficient “tau” of Kendall was used to analyze the correlation between different instruments. Results Thirty patients with RA were included. The mean age was51±11 years with a female predominance (80%). Time to complete the questionnaires was 30 seconds. The median for RADAI-5 was 3.9 (1.7 to 4.9), 4.05 for the RAPID-3 (1.91 to 5.13), 4.47 for the RAID (2.31 to 5.78).Cronbach's alpha was excellent for RADAI-5 (α=0.99), RAPID-3 (α=0.99) and RAID (α=0.99). The “tau” concordance was 0.78, 0.76, 0.74, and 0.82 between RAID and respectively RAPID3, RADAI5, DAS28ESR, CDAI. (p<0.001 was highly significant for all variables). Conclusions The reliability of the questionnaire RAID is as good ascomposite indices.The questionnaires showed a good agreement with each other and indices. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5236

Objectives To determine the factors influencing bone mineral content in patients with juvenile idiopathic arthritis. Methods A cross sectional studyin patientswith juvenile idiopathic arthritis (JIA) according to the International League of Association of Rheumatology criteria was conducted. Sociodemographic parameters and clinical data related to the disease were collected. Bone mineral content was measured by dual energy X-ray absorptiometry on Lunar Prodigy machine at the full body. Disease activity of the JIA was assessed by the number of painful joints (PJ), number of swollen joints (SJ), the visual analogic scale (VAS) pain assessed by patient (VASp) and physician (VASd), and biological parameters (ESR,CRP). Biochemical markers of bone turnover were represented by serum calcium, phosphorus and alkaline phosphatase. Normal serum calcium in children <3 years is 88-110 mg/l and for children>3 years: 90-105 mg/l. For phosphate: 40-60 mg/l. For alkaline phosphatase: 90-450 IU/l. The daily food intake was assessed by a questionnaire for 7 consecutive days. Two nutritionists analyzed the diet to identify its macronutrient and oligonutriments content. Food intake was analyzed by Bilnut Version 2.01 software 1991. Results Thirty-three patients with JIA were included. The mean age was10±4.35 years with amale predominance 54.5%. Twenty-four percent had a systemic form, 27% an oligoarticular and 48% a polyarticular form. The median disease duration was 2 years (1 - 4.5). The median duration of taking corticosteroids was 3 years (1-6). The median rate of vitamin D was 20ng/ml (13.85-31.5), for serum calcium 95 mg/l (93-97). The mean rate of phosphorus was 45mg/l ±7.36. The mean rate of alkaline phosphatase was 161UI/l ±52.The median of CMO, PJ, SJ, VASp, VAS d, ESR and CRP were respectively 1044.97g (630-1808), 3 (1-9), 1 (0 - 3), 20 (10-50) 35 (25-50.5) 20 (10.5-40). There was no correlation between bone mineral content and JIA disease activity parameters: PJ (r =0.06, p=0.77), SJ (r =0.25, p=0.23), VASp (r =0.16, p=0.46), VASd (r =0.02, p=0.91), ESR (r =0.13, p=0.54), CRP (r =0.10, p=0.64).There was no correlation between the bone mineral content and the cumulative duration and corticosteroid dose taken with respectively (r =0.15, p=0.61) (r =0.28, p=0.33).There was a positive correlation between the rate of phosphorus and bone mineral content as well as alkaline phosphatase with respectively (r =0.47, p=0.02) (r =0.41, p=0.04) while the CMO is not correlated with the rate of vitamin D (r =0.14, p=0.5) or the serum calcium levels (r =0.11, p=0.59). Conclusions This study suggests that bone mineral content was correlated with markers of bone turnover such as alkaline phosphatase and serum phosphate. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5295

Objectives To determine the factors influencing the fat body mass in patients with juvenile idiopathic arthritis. Methods A cross sectional study in patients with juvenile idiopathic arthritis (JIA) according to the International League of Association of Rheumatology criteria was conducted. Sociodemographic parameters and clinical data related to the disease were collected. Fat body mass was measured by dual energy X-ray absorptiometry on Lunar Prodigy machine at the full body. Disease activity of the JIA was assessed by the number of painful joints (PJ), number of swollen joints (SJ), thevisual analogic scale (VAS) of painassessed by patient (VASp) and physician (VASd), and biological parameters (ESR,CRP). The daily food intake was assessed by a questionnaire for 7 consecutive days. Two nutritionists analyzed the diet to identify its macronutrient and oligonutriments content. Food intake was analyzed by Bilnut Version 2.01 software 1991. Results Thirty-three patients with JIA were included. The mean age was 10±4.35 years with a male predominance (54.5%). Twenty-four percent had a systemic subtype, 27% an oligoarticular and 48% a polyarticular subtype. The median disease duration was 2 years (1-4.5). The median duration of taking corticosteroids was 3 years (1-6). The median of fat mass, PJ, SJ, VASp, VAS d, ESR and CRP were respectively 4.97g (15.96-33.45), 3 (1-9), 1 (0-3), 20 (10-50) 35 (25-50.5) 20 (10.5-40).The median content of the feed proteins, lipids and carbohydrates was respectively1.7g (0-4.75), 0.8 g (0-11.65), and 11.1g (0-32.8). There were no correlation between fat mass and disease activity of JIA parameters: PJ (r=0.27, p=0.20), SJ (r=0.29, p=0.18), VASp (r=0.06, p=0.76), VAS d (r=0.13, p=0.53), ESR (r=0.18, p=0.4), CRP (r=0.24, p=0.28). There was a positive correlation between fat mass and the cumulative dose of corticosteroids (r=0.55, p=0.04) whereas there was no correlation with duration of its use (r=0.24, p=0.41). There were no correlation between the mass fat and the protein content of feed (r=0.13, p=0.54), fat content (r=0.15, p=0.5) and carbohydrates (r=0.07, p=0.73). Conclusions This study suggests that fat mass was not correlated with the activity of JIA or the content of macronutrients in the diet but it was associated with the cumulative dose of corticosteroids parameters. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5276

BackgroundChildren and adolescents with juvenile idiopathic arthritis are at high risk of developing some particularly anxious psychological disorders. Although it is a common mental health problem in children with chronic rheumatic diseases in our country, it is not sufficiently studied.ObjectivesThe purpose of this study was to translate an assessment questionnaire of an anxiety disorders in children (SCARED) into classical Arabic and to measure its reliability and psychometric validity.MethodsA classic Arabic version of SCARED was developed and evaluated using a sample of 47 children suffering from juvenile idiopathic arthritis. A questionnaire of 41 items (5 areas) was completed by our patients at two different moments in time with a 48 hours interval. Studies on test-retest reliability and internal consistency were performed using the intra-class correlation coefficient (ICC) and the Cronbach's coefficient α. The validity of the Arabic version of the SCARED was assessed using a sample of 47 children matched for age and sex.Criteria of judgment: The primary outcome was the reliability and psychometric validity of the SCARED.ResultsA total of 47 children with juvenile idiopathic arthritis (according to the criteria of the ILAR 2001) were tested along with 47 other children without JIA who formed the control group. The first group had a mean age of 11.5±3.3 years, with a male predominance (59.6%), 31% had joint Oligo form, the median duration of disease was 4 years [2–6]. The median Jadas of our patients was 8 [3; 14], indicating moderate disease activity. We demonstrated high test-retest reliability (ICC >0.994) and high internal consistency (Cronbach's α of 0.997). We have shown that the overall coefficients of test-retest reliability were high for the total score and for each SCARED domain. In terms visible validity, the questionnaire was understandable and was able to accurately measure the various aspects of anxiety within children. We found a strong correlation with measures of depression, sleep disorders and quality of life assessed by CDRS (r =0.096 and p=0.04), the CSHQ (r =0.304/p=0.03) and PedsQL4, 0 (r =0.252/p=0.04). We found significant differences in the total scores and domains between the JIA group and the control group, denoting a good discriminate validity of the SCARED.ConclusionsThe results provided evidence of the validity and reliability of the Arabic version of the SCARED for Moroccan children with juvenile idiopathic arthritis. The questionnaire is an appropriate instrument to detect anxiety within children and could be useful in clinical practice, research and teaching.Disclosure of InterestNone declared

BackgroundObesity is a major risk factor for osteoarthritis of the knee. However, the fat and muscle have different effects on the pathogenesis of the disease.ObjectivesThe purpose of this study was to examine the relationship between body composition and knee structure especially cartilage defects, osteophytes and bone marrow lesions (BMLS).MethodsThis is a cross-sectional study including patients with primary knee OA. Demographics, clinical and laboratory characteristics for the disease were collected. All patients underwent magnetic resonance imaging (MRI) of the dominant knee. The results were interpreted according to WORMS system [1] (whole organ magnetic resonance imaging score). The body composition was measured using DEXA (dual energy X-ray absorptiometry). The regression was used to assess the association of body mass (fat mass and musculoskeletal mass) with MRI data in particular: cartilage defects, osteophytes and BMLs.ResultsTwenty patients with osteoarthritis of the knee were included in the study, 85% were female. The mean age was 59.3±10.3 years. The patients had a mean body mass index 30.1±4.7 kg/ m2. The functional discomfort of patients assessed by the WOMAC averaged 38.3±11.3. The mean of total fat mass was 32.6±10.8 kg. The mean of musculoskeletal mass was 15.8±2.5 kg. The fat mass was associated with increased cartilage defects in univariate analysis (p=0.04). However, musculoskeletal mass was not significantly associated with cartilage defects or osteophytes or BMLs.ConclusionsThis study suggests that there is an association between fat mass and increased cartilage defects, however we do not find an association between body composition in particular musculoskeletal mass and knee injuries in OA. Further studies are needed to confirm these results.ReferencesOsteoArthritis and Cartilage (2004) 12, 177–190Disclosure of InterestNone declared

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