Biotransformation of [2-14C]-1-AUyl-3,5-dethyl-6-chloronrac~ and Synthesis of Some Possible Degradation ProductsAfter intravenous application of [2-'4C]-1-allyl-3,5-diethyl-6-chlorouracil in rabbits, the major part of the activity is eliminated in the urine and faeces. The major metabolite has been isolated by thick layer and column chromatography. It was identified as 6,8-diethyl-2-(hydroxymethyl)tetrahydrooxazo-10-[3,2-c]pyrimidine-5,7(4H, 6H)-dione (13) by 'H-NMR and mass spectroscopy and by an independent synthesis. The synthesis of the potential degradation products 2-12 which may also occur as metabolites is described.
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