Antistaphylococcal Activity of Seeds of Psoralea corylifolia

Gaind, K. N.; Dar, Rabiya; Kaul, R.

doi:10.1002/jps.2600531141

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Furthermore, testing the antiviral and anti-tumor actions of S. occidentallis, revealed no activity of the extract [76]. The seeds of S. occidentalis have proven to possess strongly antibacterial activity against of S. aureus, B. subtilis, B. proteus and Vibrio cholera and antifungal action against A. flavus, A. niger and Trichophyton mentagrophytes [77][78][79].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Review on the Ethnobotany, Phytochemical and Pharmacological Profile of Senna occidentalis L. (Fabaceae): Potential Application as Remedy in the Treatment of Dysmenorrhea

Kalombo

Mukeba

Idrissa

et al. 2022

EJMP

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Senna occidentalis L. has been used in several traditional medicines against various diseases and this is based on its botanical, ethnopharmacology, and phytochemistry profiles. This powerful herb is recognized for its antibacterial, antifungal, antidiabetic, anticancer, antimutagenic, protective, and inflammatory hepatic activity. Multiple chemical compounds, including achrosine, aloe-emodin, emodin, anthraquinones, etc., have been isolated from this plant. The results of this bibliographic research thus presented in this review have demonstrated the ability of certain extracts from S. occidentalis L. to lower the lipid peroxide content, the activity of gamma-glutamyl transpeptidase and phospholipase A2 in exudates of the granuloma of cotton pellets, thus resulting in a reduced availability of arachidonic acid, an important precursor in the biosynthesis of prostaglandins, which are the only likely source and/or cause of dysmenorrhea. Thus, based on its phytochemical profile and its pharmacological properties, it is therefore suggested that S. occidentalis would be a potential and effective remedy in the treatment of dysmenorrhea.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Review on the Ethnobotany, Phytochemical and Pharmacological Profile of Senna occidentalis L. (Fabaceae): Potential Application as Remedy in the Treatment of Dysmenorrhea

Kalombo

Mukeba

Idrissa

et al. 2022

EJMP

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“…In the 1970s, Psoralea corylifolia is widely distributed in Southeastern Asian countries had inspired scientific interest with clinical applications, 3) and then it is officially listed in the Pharmacopoeia of the traditional Chinese medicine (TCM) (Edit 2010 Vol. II).…”

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confidence: 99%

Effects of Psoralen as an Anti-tumor Agent in Human Breast Cancer MCF-7/ADR Cells

Wang

Chen

Han

et al. 2016

Biological & Pharmaceutical Bulletin

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Psoralen is a major active component of Psoralea corylifolia. In the present study, we analyzed psoraleninduced changes in human breast cancer MCF-7/ADR cells and investigated the underlying mechanisms of the anticancer effect on MCF-7/ADR cells. We measured cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cytotoxicity and multidrug resistance (MDR) reversal activity of psoralen. The cell cycle distribution and apoptosis, accumulation and efflux of rhodamine123 (Rh123), and P-glycoprotein (P-gp) expression levels of MCF-7/ADR cells treated with psoralen were all detected by flow cytometry (FCM). We assessed P-gp ATPase activity by monitoring ATP consumption. We evaluated the activity of nuclear factor-kappaB (NF-κB) and the expression of E-cadherin, vimentin and α-smooth muscle actin (SMA) involved in regulating epithelial-mesenchymal transition (EMT). The results showed that psoralen inhibited the proliferation of MCF-7/ADR cells as shown by G0/G1 phase arrest rather than encouraging apoptosis. It was also observed that psoralen reversed MDR through inhibiting ATPase activity rather than reducing P-gp expression. Our results further showed that psoralen inhibited the migration abilities of MCF-7/ADR cells by repressing EMT possibly through inhibiting the activation of NF-κB. Our findings provided a systematic and detailed description of the anti-cancer effect of psoralen on MCF-7/ ADR cells for the exploration of natural compounds as novel anticancer agents.Key words psoralen; multidrug resistance (MDR); P-glycoprotein (P-gp) ATPase; cell cycle arrest; epithelial-mesenchymal transition (EMT)The breast cancer incidence in Asia is rising as the leading cause of cancer death among women in the world. It is a systemic disease, with the primary tumor representing the localized form of the disease. At present, the main treatment for breast cancer include chemotherapy, surgery, radiotherapy, hormonal therapy and targeted antibodies. The overall treatment effect is reassuring, but still facing many thorny issues, lacking of specificity and poor avoidance of recurrence. The chemotherapy resistance, the metastasis and recurrence, these are all the reasons for breast cancer treatment failure. Plantderived natural products play a very important role in the area of cancer therapy research as a source of numerous currently used anticancer agents 1) including vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and many others.2) Therefore, there is a great need for continuous search for new antineoplastic agents from plant sources.In the 1970s, Psoralea corylifolia is widely distributed in Southeastern Asian countries had inspired scientific interest with clinical applications, 3) and then it is officially listed in the Pharmacopoeia of the traditional Chinese medicine (TCM) (Edit 2010 Vol. II). As is known to all, two of the main ingredients of furanocoumarins are psoralen and isopsoralen which play a role in cell proliferation and diff...

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Cullen corylifolium (L.) Medicus (Fabaceae/Leguminosae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Antistaphylococcal Activity of Seeds of Psoralea corylifolia

Cited by 5 publications

References 2 publications

Review on the Ethnobotany, Phytochemical and Pharmacological Profile of Senna occidentalis L. (Fabaceae): Potential Application as Remedy in the Treatment of Dysmenorrhea

Review on the Ethnobotany, Phytochemical and Pharmacological Profile of Senna occidentalis L. (Fabaceae): Potential Application as Remedy in the Treatment of Dysmenorrhea

Effects of Psoralen as an Anti-tumor Agent in Human Breast Cancer MCF-7/ADR Cells

Cullen corylifolium (L.) Medicus (Fabaceae/Leguminosae)

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