Species of Cassia (family Caesalpinaceae) are well known in India and other tropical countries for their medicinal values. This study evaluates the efficacy of the methanol extract of the leaves of Cassia javanica L. on paracetamol-induced liver damage in experimental rats. The animals were randomly divided into six groups of five animals each. While group I served as the normal control, group II-V serve as the test groups, and group VI as C. javanica control group. Hepatotoxicity was induced in the test groups via oral administration of paracetamol (2 g/kg b.wt). While group III-V were treated for 14 days with 125 mg/kg, 250 mg/kg and 500 mg/kg b.wt of C. javanica methanol extract respectively, group II served as positive control and was left untreated. The degree of hepatoprotection was assessed by estimating the levels of aspartate transaminases (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and tissue protein. Administration of methanol extract of C. javanica elicited protective action in groups III-V when compared to group II as the cell progress towards normalization evidenced by the significant decline in the elevated levels of marker enzymes (AST, ALT, ALP) and total bilirubin and an increase in tissue protein. The findings indicate that C. javanica has a hepatoprotective action against paracetamol-induced hepatic damage in Wistar rats and indeed validate its traditional use in the treatment of liver damage.
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