In both of the title compounds, C(23)H(19)ClN(2)O, (I), and C(23)H(18)Cl(2)N(2)O, (II), the molecular packing is influenced by weak intermolecular C-H.O and C-H.pi interactions, but despite the chemical similarity of the compounds, the packing in (II) is entirely different from that observed in (I).

In the title compound, C(31)H(40)N(2)O x H(2)O, the outer two six-membered rings are in chair conformations, while the central ring is in an 8 beta,9 alpha-half-chair conformation. The five-membered ring adopts a 13 beta-envelope conformation and the cyanobenzylidene moiety has an E configuration with respect to the hydroxyl group at position 17. The steroid nuclei are linked by intermolecular O[bond]H...O and O[bond]H...N hydrogen bonds to form a molecular network. The molecular packing has an interesting feature, with the steroids aligned parallel to the b axis, forming a closed loop through hydrogen bonds linked via water molecules.

Key indicatorsSingle-crystal X-ray study T = 273 K Mean (C-C) = 0.002 Å R factor = 0.035 wR factor = 0.102 Data-to-parameter ratio = 13.4For details of how these key indicators were automatically derived from the article, see

Key indicatorsSingle-crystal X-ray study T = 273 K Mean (C-C) = 0.002 Å R factor = 0.037 wR factor = 0.104 Data-to-parameter ratio = 14.5For details of how these key indicators were automatically derived from the article, see

In the title compound, C18H19N3O2·H2O, the piperidine ring adopts a distorted boat conformation. In the solid state, the mol­ecules are linked by inter­molecular O—H⋯O and O—H⋯N hydrogen bonds involving water mol­ecules.

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Key indicatorsSingle-crystal X-ray study T = 293 K Mean '(C±C) = 0.002 A Ê R factor = 0.045 wR factor = 0.134 Data-to-parameter ratio = 16.6For details of how these key indicators were automatically derived from the article, see