In recent years heterocyclic Schiff base metal complexes attract more attention in biological application and also showing interesting co-ordination chemistry. In this research article a novel heterocyclic methyl-substituted pyridine Schiff base transition metal complexes of Fe(III), Co(III), Cu(II), and Ni(II) have been design and synthesized by reacting metal acetate or metal salts (FeCl3, CoOAc, CuOAc, NiOAc), with substituted heterocyclic ligand. All newly synthesized metalcomplexes were characterized by spectroscopic data and screened for elemental analysis, FT-IR, ESR, Magnetic susceptibility and TGA. The Electronic spectra and magnetic susceptibility measurements indicates that square planer and octahedral geometry of these complexes also suggest their structure in which (N, O) group acts as bidentate ligand. The thermal stability, decomposition rate and thermodynamic parameters of synthesized metal complexes were calculated by Freeman Carroll method. Also the biostatistical data of antimicrobial and anti-oxidant activities of synthesized metal complexes indicates moderate to good results. Graphic abstract

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In last decades Aliphatic, Aromatic and heterocyclic compounds containing one or two heteroatoms are gain attention of researchers knowing importance of Schiff's base and its application in pharmaceuticals and drug manufacturing as well as in the synthetic compounds of biological interest.[1] Here we reviewed some synthetic methods, Schiff's base and its complexes formed from condensation of the carbonyls and amines keeping its application regarding biological activity in global prospective. Schiff bases are a popular class of compounds with interesting biological properties. Schiff bases are also versatile metal complexing ligands and have been used to coordinate almost all d-block metals as well as lanthanides and found various application were patented its therapy of Schiff bases.[2]

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