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Future tonne-scale liquefied noble gas detectors depend on efficient light detection in the VUV range. In the past years Silicon Photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large area avalanche photodiodes. The next generation double beta decay experiment, nEXO, with a 5 tonne liquid xenon time projection chamber, will use SiPMs for detecting the 175 nm xenon scintillation light, in order to achieve an energy resolution of σ/Qββ = 1 %. This paper presents recent measurements of the VUV-HD generation SiPMs from Fondazione Bruno Kessler in two complementary setups. It includes measurements of the photon detection efficiency with gaseous xenon scintillation light in a vacuum setup and dark measurements in a dry nitrogen gas setup. We report improved photon detection efficiency at 175 nm compared to previous generation devices, that would meet the criteria of nEXO. Furthermore, we present the projected nEXO detector light collection and energy resolution that could be achieved by using these SiPMs. Index Terms-silicon photomultiplier, xenon detectors, photo detectors, vacuum ultra-violet light, nEXO I. NEUTRINO-LESS DOUBLE BETA DECAY AND NEXO N eutrino-less double beta decay (0νββ) is a hypothetical nuclear decay where two neutrons decay into two protons and two electrons are emitted but no anti-neutrinos are present in the final state. The observation of this process would have a fundamental impact on the Standard Model of Particle Physics, specifically showing a violation of lepton number conservation (|∆L| = 2), and would imply that the neutrino is a Majorana fermion [1], independently of the actual process enabling the decay [2]. Furthermore, the half-life of the decay would shed light on the absolute neutrino mass scale [3]. The nEXO collaboration plans to build a cylindrical singlephase time projection chamber (TPC) filled with 5 tonnes of liquid xenon (LXe), with 90 % enrichment in 136 Xe [4]. nEXO takes advantage of the experience from its predecessor EXO-200 [5], but will incorporate new light and charge detectors [6]. Together with cold electronics sitting inside the LXe, this allows nEXO to achieve an energy resolution of σ/Q ββ = 1 % for the 0νββ decay of 136 Xe (2458.07 ± 0.31 keV [7], [8]).In particular, instead of the EXO-200 Large Area Avalanche Photo-diodes (LAAPDs), nEXO will use Silicon Photomultipliers (SiPMs) for the detection of xenon scintillation light. The SiPMs will fully cover the lateral surface of the cylinder with a total photo-sensitive area of about 4 m 2 , as shown in Figure 1. The devices will be immersed in LXe and placed in the high field region behind the field shaping rings of the TPC field cage [9]. The performance of SiPMs has improved significantly over the past decade and they are especially interesting because of their high gain, on the order of 10 6 , and their single photon resolution capability.The half-life sensitivity of nEXO to the 0νββ decay of 136 Xe is projected to be 9.5 × 10 27 yr for 90 % C.L. after 10 years o...

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In a double-blind controlled study lasting 8 weeks, 50 anxious psychoneurotic outpatients with a primary diagnosis of generalized anxiety or panic disorder were randomly assigned to alprazolam (n=30), a new benzodiazepine, or placebo (n=20), after a washout period of 1 week. Alprazolam at dosages between 0.25 and 3 mg/day was found to be significantly better than placebo in the treatment of either disorder. The finding that alprazolam was effective in the treatment of panic disorder is of interest as this diagnostic category is usually treated with tricyclic antidepressants or MAO inhibitors.