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International audienceThree-dimensional stationary structure of the flow over a backward-facing step is studied experimentally. Visualizations and Particle Image Velocimetry (PIV) measurements are investigated. It is shown that the recirculation length is periodically modulated in the spanwise direction with a well-defined wavelength. Visualizations also reveal the presence of longitudinal vortices. In order to understand the origin of this instability, a generalized Rayleigh discriminant is computed from a two-dimensional numerical simulation of the basic flow in the same geometry. This study reveals that actually three regions of the two-dimensional flow are potentially unstable through the centrifugal instability. However both the experiment and the computation of a local Görtler number suggest that only one of these regions is unstable. It is localized in the vicinity of the reattached flow and outside the recirculation bubble

In this study, a passive flow control experiment on a 3D bluff-body using vortex generators (VGs) is presented. The bluff-body is a modified Ahmed body (Ahmed in J Fluids Eng 105:429-434 1983) with a curved rear part, instead of a slanted one, so that the location of the flow separation is no longer forced by the geometry. The influence of a line of non-conventional trapezoïdal VGs on the aerodynamic forces (drag and lift) induced on the bluffbody is investigated. The high sensitivity to many geometric (angle between the trapezoïdal element and the wall, spanwise spacing between the VGs, longitudinal location on the curved surface) and physical (freestream velocity) parameters is clearly demonstrated. The maximum drag reduction is -12%, while the maximum global lift reduction can reach more than -60%, with a strong dependency on the freestream velocity. For some configurations, the lift on the rear axle of the model can be inverted (-104%). It is also shown that the VGs are still efficient even downstream of the natural separation line. Finally, a dynamic parameter is chosen and a new set-up with motorized vortex generators is proposed. Thanks to this active device. The optimal configurations depending on two parameters are found more easily, and a significant drag and lift reduction (up to -14% drag reduction) can be reached for different freestream velocities. These results are then analyzed through wall pressure and velocity measurements in the near-wake of the bluff-body with and without control. It appears that the largest drag and lift reduction is clearly associated to a strong increase of the size of the recirculation bubble over the rear slant. Investigation of the velocity field in a crosssection downstream the model reveals that, in the same time, the intensity of the longitudinal trailing vortices is strongly reduced, suggesting that the drag reduction is due to the breakdown of the balance between the separation bubble and the longitudinal vortices. It demonstrates that for low aspect ratio 3D bluff-bodies, like road vehicles, the flow control strategy is much different from the one used on airfoils: an early separation of the boundary layer can lead to a significant drag reduction if the circulation of the trailing vortices is reduced.

Pre-clinical bone cancer pain models mimicking the human condition are required to respond to clinical realities. Breast or prostate cancer patients coping with bone metastases experience intractable pain, which affects their quality of life. Advanced monitoring is thus required to clarify bone cancer pain mechanisms and refine treatments. In our model of rat femoral mammary carcinoma MRMT-1 cell implantation, pain onset and tumor growth were monitored for 21 days. The surgical procedure performed without arthrotomy allowed recording of incidental pain in free-moving rats. Along with the gradual development of mechanical allodynia and hyperalgesia, behavioral signs of ambulatory pain were detected at day 14 by using a dynamic weight-bearing apparatus. Osteopenia was revealed from day 14 concomitantly with disorganization of the trabecular architecture (µCT). Bone metastases were visualized as early as day 8 by MRI (T1-Gd-DTPA) before pain detection. PET (Na18F) co-registration revealed intra-osseous activity, as determined by anatomical superimposition over MRI in accordance with osteoclastic hyperactivity (TRAP staining). Pain and bone destruction were aggravated with time. Bone remodeling was accompanied by c-Fos (spinal) and ATF3 (DRG) neuronal activation, sustained by astrocyte (GFAP) and microglia (Iba1) reactivity in lumbar spinal cord. Our animal model demonstrates the importance of simultaneously recording pain and tumor progression and will allow us to better characterize therapeutic strategies in the future.

The LabPET is an avalanche photodiode (APD) based digital PET scanner with quasi-individual detector read-out and highly parallel electronic architecture for high-performance in vivo molecular imaging of small animals. The scanner is based on LYSO and LGSO scintillation crystals (2×2×12/14 mm3), assembled side-by-side in phoswich pairs read out by an APD. High spatial resolution is achieved through the individual and independent read-out of an individual APD detector for recording impinging annihilation photons. The LabPET exists in three versions, LabPET4 (3.75 cm axial length), LabPET8 (7.5 cm axial length) and LabPET12 (11.4 cm axial length). This paper focuses on the systematic characterization of the three LabPET versions using two different energy window settings to implement a high-efficiency mode (250–650 keV) and a high-resolution mode (350–650 keV) in the most suitable operating conditions. Prior to measurements, a global timing alignment of the scanners and optimization of the APD operating bias have been carried out. Characteristics such as spatial resolution, absolute sensitivity, count rate performance and image quality have been thoroughly investigated following the NEMA NU 4-2008 protocol. Phantom and small animal images were acquired to assess the scanners' suitability for the most demanding imaging tasks in preclinical biomedical research. The three systems achieve the same radial FBP spatial resolution at 5 mm from the field-of-view center: 1.65/3.40 mm (FWHM/FWTM) for an energy threshold of 250 keV and 1.51/2.97 mm for an energy threshold of 350 keV. The absolute sensitivity for an energy window of 250–650 keV is 1.4%/2.6%/4.3% for LabPET4/8/12, respectively. The best count rate performance peaking at 362 kcps is achieved by the LabPET12 with an energy window of 250–650 keV and a mouse phantom (2.5 cm diameter) at an activity of 2.4 MBq ml−1. With the same phantom, the scatter fraction for all scanners is about 17% for an energy threshold of 250 keV and 10% for an energy threshold of 350 keV. The results obtained with two energy window settings confirm the relevance of high-efficiency and high-resolution operating modes to take full advantage of the imaging capabilities of the LabPET scanners for molecular imaging applications.

A classical actuator is used to control the drag exerted on a bluff body at large Reynolds number ͑Re = 20000͒. The geometry is similar to a backward-facing step whose separation point is modified using a rotating cylinder at the edge. The slow fluctuations of the total drag are directly measured by means of strain gauges. As shown by visualizations, the actuator delays the separation point. The size of the low-pressure region behind the body is decreased and the drag reduced. It is found that the faster the rotation of the cylinder, the lower the drag. In a first study, the goal of the control is for the system to reach a drag consign predetermined by the experimentalist. The control loop is closed with a proportional integral correction. This adaptive method is shown to be efficient and robust in spite of the large fluctuations of the drag. In the second method, the system finds itself its optimal set point. It is defined as the lowest cost of global energy consumption of the system ͑drag reduction versus energy used by the actuator͒. For this purpose, an extremum seeking control method is applied in order to deal with the large background noise due to turbulence. It consists in a synchronous detection of the response measured in the drag measurements to a modulation of the actuator. The phase shift and amplitude of the modulation estimate the local gradient of the total energy function. With this gradient estimation, the system goes to the minimum of global power consumption by itself. The system is found to be also robust and reacts successfully to changes of the external mean flow. This experiment attests to the real efficiency of local active control in reducing autonomously the global energy consumption of a system under turbulent flow.