The swface-enhanced Raman spectra (SERS) of dopamine, norepinephrlne, epinephrine, eplnlne, isoproterenol, 3meth-oxytyramlne, and oatechd In pH 7.2 buffers on a silver ektrod@ are reported. Catechol and the c a t -are shown to be COordlMted to diver through both oxygens. The methoxylated derlvatlve Is a monodentate complex. Intenskies maximize near -0.9 V vs saturated calomel electrode. The strongest bands In the spwtra are phendic carbon-oxygen stretches and the vlOb modes around 1270 and 1480 cm-l, respectively. Ascorbate, acetylchdlne, glutathione, L-Dopa, and the catecholamine acetlc acid metabolites are SERShracHveunderthemeasuementcondltknr. Dopamkre detectlon lM for the vl Ob band Is 3 X lo-' Y wlth a 10-s measurement tlme.