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Purpose The purpose of this paper is to print a thermolabile drug-containing tablet using the fused deposition modeling (FDM) technique and analyze its mechanical, pharmaceutical and environmental feasibility using a variety of tests. Design/methodology/approach Ascorbic acid (Vitamin C) is the thermally-sensitive drug impregnated into polyvinyl alcohol excipient using ethanol-water mixture and printed by an FDM printer by varying three parameters without using any external stabilizing agent. Afterward, Taguchi analysis has been performed on these parameters to recognize the significant factors and interactions. Besides this, a regression model has been obtained based on the dissolution data. Various thermo-mechanical and pharmaceutical tests have been carried out to confirm the feasibility. Finally, a life cycle assessment (LCA) analysis has been carried out to compare it with the existing tableting method by considering the environmental impacts. Findings The dissolution profile was found to follow the Korsmeyer-Peppas model, where the drug release occurred both by dissolution and erosion. Further, the infill percent has been found as the most significant parameter. The characterization tests and imaging outputs proved the fidelity of this attempt. Finally, the three-dimensional printed method was found to be more environmentally sustainable than the existing conventional tableting process. Originality/value LCA on a printed tablet is a one-of-a-kind attempt. Thus, this research attempt delivered another approach to print personalized tablets at a temperature lower than prescribed temperatures with required release behavior and can contribute toward the quest of sustainable personalized medication.

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PurposeThe aim of this paper is to review and analyze the research literature on the health and safety issues of migrant workers in the construction industry from 2000 to 2022.Design/methodology/approach5 steps method is used to conduct a systematic review to achieve the objectives. After scanning two authoritative search engines “Web of Science” and “Scope”, 60 articles are selected from 225 publications for identification and review. These identified articles are classified by research fields, countries and time span.FindingsThe review finds that with the increasing influence of migrant construction workers, the number of publications on the health and safety of migrant workers has shown a rapid upward trend. Moreover, language barriers are the most dominant safety risk factors encountered by on-site migrant workers. This systematic literature review also summarizes the definition of migrant workers and solutions to reduce safety risk factors.Originality/valueThe research data on the health and safety issues and risk factors of migrant workers in the construction industry is still limited. This literature review summarizes the research trends and contributions of the literature in this field in the past 22 years and provides theoretical support for future research on the safety management of the migration construction field.

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